Cheapest Progesterone Without Insurance: 2026 Prices and How to Get It
By The HRT Index Editorial Team · Last verified:
The HRT Index is an independent comparison resource for HRT telehealth providers. Some links below are affiliate links. If you use them, we may earn a commission at no extra cost to you. It never changes the prices you pay or the options we pick. This is research and education, not medical advice. Full disclosure →
The cheapest progesterone without insurance is generic micronized progesterone— the same medicine as brand-name Prometrium, just without the brand price. As of June 2026, a one-month supply runs about $11 to $18 with a free pharmacy coupon, and a larger supply drops it to as little as about $8 a month. The brand-name version can cost $496 for a single month. So if your pharmacy just quoted you a scary number, take a breath. You’re very likely overpaying, and the fix is simple.
Here’s the honest part, up front: if you already have a prescription, the cheapest way to get progesterone earns us nothing. There’s no affiliate link for a $12 generic. We’re going to tell you to go get it anyway. The only place we can actually save you money andtime is if you don’t have a prescription yet — and even then, we’ll point you to the cheapest legal route, not the priciest one.
Below is the full picture: real, current prices from every major cash pharmacy, what to do based on your exact situation, and the one mistake that makes people pay 20 times more than they need to.
The quick answer, by situation:
| Your situation | Cheapest first move | Roughly what you’ll pay |
|---|---|---|
| You already have a prescription | Fill the generic at a cash pharmacy or with a coupon | ~$8–$18 / month |
| You don’t have a prescription yet | A one-time online visit, then fill the generic | ~$37 once, then ~$8–$18 / month |
| You want care managed for you | A flat-fee menopause program | ~$39–$99 / month |
| You only want the brand Prometrium | Ask if the generic works for you first | ~$496 / month for brand |
Answer a few quick questions — dose, supply, your state — and see your single lowest-cost option.
Find your cheapest path in 30 seconds →See also: how to get micronized progesterone online · HRT cost guide 2026 · how to get progesterone prescribed online
What’s the cheapest progesterone without insurance?
The cheapest progesterone without insurance is generic micronized progesterone bought through a cash-pay pharmacy or with a free coupon. A one-month supply usually costs about $11 to $18, and buying a longer supply can bring it down to roughly $8 a month. The brand-name version, Prometrium, costs far more for the same active medicine.
“Micronized progesterone” just means the progesterone is ground into tiny particles so your body absorbs it better. It’s the standard form used in hormone therapy, and it comes as a 100 mg or 200 mg oral capsule.
Here’s what the same generic prescription costs across the main cash-pay options:
| Where you fill it | Example cash price | Good to know |
|---|---|---|
| Marley Drug (mail-order) | $14.50/month on a 3-month supply, or $92 for a 12-month supply (360 tablets) — about $7.67/month | Flat cash price, no coupon needed; FDA-approved; free delivery to all 50 states |
| Cost Plus Drugs (mail-order) | About $9.45 for 30 capsules of 100 mg (and ~$11.86 for 200 mg), plus shipping | Simple, transparent pricing; ships to your door |
| GoodRx / SingleCare coupon (local pharmacy) | About $18 for 30 capsules of 100 mg with GoodRx; as low as ~$11 at some pharmacies | Free to use; the price changes by pharmacy and ZIP code |
| Drugs.com price-guide low | From $11.77 for 30 (100 mg); $17.54 for 30 (200 mg) | A solid benchmark to compare against |
| Retail, no coupon | Around $420 for 90 capsules of 100 mg (per SingleCare) | This is usually the “scary quote.” Don’t accept it. |
| Brand-name Prometrium | $496.54 for 30 (100 mg); about $1,820 for 90 | Same active medicine as the generic, far higher price |
Prices as of , from each pharmacy’s listed price, GoodRx, SingleCare, and the Drugs.com price guide. Prices change — check the live price before you buy.
Progesterone 100 mg vs 200 mg price without insurance
The price tracks the dose and how many capsules you buy. Here’s a quick side-by-side of the common amounts:
| Strength and supply | Approx. cash price | Source |
|---|---|---|
| 100 mg, 30 capsules | ~$9.45 (Cost Plus); ~$11.77 (Drugs.com); ~$18 (GoodRx) | Cost Plus / Drugs.com / GoodRx |
| 100 mg, 360 (12-month) | $92 total — about $7.67/month | Marley Drug |
| 200 mg, 30 capsules | ~$11.86 (Cost Plus); ~$17.54 (Drugs.com) | Cost Plus / Drugs.com |
| 200 mg, 90 capsules | ~$52.18 (GoodRx) | GoodRx |
One honest admission, because it matters.The cheapest options on that table — the generic at Marley, Cost Plus, or with a coupon — pay us nothing. There’s no commission on a $12 fill, so we have zero reason to send you anywhere else. We’re telling you to do exactly that. The only readers we earn anything from are the ones who don’t have a prescription yet and need help getting one fast — and even then, we point you to the cheapestroute. That’s the whole deal.
Already holding a prescription?Skip the subscriptions. Compare a coupon price against Marley or Cost Plus and fill the generic. That’s your cheapest move, full stop.
Have your prescription? Compare cash-fill routes →Is generic progesterone the same as Prometrium?
Yes. Generic micronized progesterone is the FDA-approved generic of Prometrium — the same active ingredient, the same dose, and the same capsule form. The U.S. Food and Drug Administration (FDA) requires generics to be therapeutically equivalent to the brand, so the generic works the same way in your body. The main difference is the price tag.
This is the fear we hear most: “If it’s that much cheaper, is it real? Is it safe?”Fair question, and the answer is reassuring. A generic isn’t a knock-off. It’s the same medicine, made to FDA standards, just without the brand-name markup. Unless your prescriber has a specific reason to require the brand, the generic is the smart, safe, cheap choice.
Peanut oil note:Micronized progesterone capsules — both Prometrium and the generic — are made with peanut oil. If you have a peanut allergy, tell your clinician and pharmacist before you fill it, because there are other options.
Where is progesterone cheapest — Cost Plus, Marley, GoodRx, or your pharmacy?
For most people, the lowest price comes from a flat-rate mail-order pharmacy like Marley Drug or Cost Plus Drugs, or a free GoodRx or SingleCare coupon at a local pharmacy.Prices swing a lot by pharmacy and location, so it’s worth comparing two or three before you fill. Just avoid the full retail price and the brand price.
Here’s how the cheapest routes actually work:
- Marley Drug is a licensed mail-order pharmacy that sells FDA-approved generic progesterone at a flat cash price — $14.50 a month on a 3-month supply, or $92 for a full year (360 tablets), which works out to about $7.67 a month.No coupon needed, free delivery to all 50 states, and you need a valid prescription. For a stable, ongoing prescription, this is often the lowest price you’ll find.
- Cost Plus Drugs uses simple, transparent pricing and lists 100 mg progesterone at about $9.45 for 30 capsules (and 200 mg around $11.86), plus shipping. It ships nationwide and is a strong pick if you want a smaller supply by mail.
- GoodRx and SingleCare are free coupon programs (not insurance) you show at the pharmacy counter. A coupon can knock a $420 retail quote down to around $33 for 90 capsules, or roughly $18 for 30. The catch: the price changes by location, so check it for your ZIP.
- Your own pharmacy’s cash priceis sometimes lower than your insurance copay. Ask the pharmacist to run the cash price too. It’s free to ask, and people are often surprised.
A simple money-saver: if your dose is stable and your clinician agrees, ask for a 90-day or longer supply. The per-capsule price almost always drops — that’s exactly how Marley gets to $7.67 a month.
Not sure which route is cheapest for your dose and state? A price range only gets you so far. Our free quiz runs your exact situation.
See your cheapest pharmacy option →Which progesterone option is cheapest for your situation?
The cheapest option comes down to one question: do you already have a prescription?If you do, fill the generic and you’re done — about $8 to $18 a month. If you don’t, a one-time telehealth visit plus the generic is the cheapest legal route. If you’d rather have a clinician manage everything for you, a flat-fee program costs more but does more.
This table shows your real, all-incost — the visit plus the medicine — by situation:
| Your situation | Cheapest legitimate path | First month, all-in | Ongoing / month | Why it fits |
|---|---|---|---|---|
| You have a prescription | Generic at Marley, Cost Plus, or a coupon | ~$8–$18 | ~$8–$18 | The drug is cheap. The only cost is the medicine. (We earn nothing here — and it’s still your best move.) |
| No prescriber, want cheapest | One-time Sesame visit (~$37), then fill the generic (affiliate) | ~$37 + ~$8–$18 | ~$8–$18 (drug only) | You pay for the visit once. Refills are just the cheap generic. |
| You want to use insurance | Midi Health (in-network with many PPOs) (affiliate) | Often a copay + ~$12 drug | Drug copay or generic price | Best if you have commercial insurance and want ongoing menopause care. |
| You want flat-fee managed care | Hers (from ~$79/month for oral medication) (affiliate) | ~$79 | ~$79 | One price covers the visit, the medicine, and ongoing provider access. |
| You want bundled care with messaging and delivery | Winona (progesterone capsules from ~$39/month) (affiliate) | ~$39 | ~$39 | A bundled option if you want everything handled in one place. |
Provider prices as listed by each company, June 10, 2026. Verify current pricing before you buy.
What if you don’t have a prescription? The cheapest way to get one.
Progesterone is prescription-only, so the cheapest legal way to get it without a prescriber is a low-cost online visit, then a cash-pharmacy fill. Sesame is the cleanest fit for this: its visits start at around $37with no insurance, and a licensed clinician can send a prescription to the pharmacy you choose — where you then pay the ~$12 generic price. That’s roughly $37 the first month, then just the cost of the generic.
First, the worry: “Is an online prescription legit?”Yes — when it’s a licensed clinician doing a real evaluation. Sesame connects you with licensed providers, and the prescription goes to a real pharmacy under your name. Helpful to know: progesterone is not a controlled substance, so there’s no extra red tape — a licensed clinician who can treat you in your state can prescribe it after an appropriate evaluation.
Second, the math. A one-time visit plus a cheap generic beats a monthly subscription if all you need is the medicine. About $37 once, then $8 to $18 a month — versus $39 to $99 every single month.
The honest part, because you deserve it straight:
The cheapest way to use Sesame is a single, pay-per-visit appointment — you don’t need a subscription at all. You get evaluated, get your prescription, and fill the cheap generic. Sesame alsooffers an ongoing menopause membership (visits, labs, and unlimited chat for about $99/month), and that’s a fine option if you want a clinician following you over time. But for the cheapest route, you just need the one visit. If ongoing, managed care is what you’re really after, Midi (affiliate) (great with insurance) or a flat-fee program like Hers (affiliate) may suit you better.
It’s a low-commitment way to see if a visit fits your situation. You only pay if you book. See our Sesame HRT review for a full breakdown.
Want to use insurance instead? How Midi compares.
If you have insurance you’d rather use, Midi Health is in-network with many PPO plans and sends your progesterone prescription to your pharmacy — so you often pay only a copay plus the low generic price. Midi is built for ongoing menopause care, not just a one-time script, which makes it a strong fit if you want a clinician relationship and you have commercial insurance.
Here’s the trade-off, stated plainly so you can decide:
Midi cannot treat Medicaid or Medi-Cal patients at this time, even if you pay cash. It’s not covered by Medicareeither — though if you’re on Medicare, you can still use Midi as a self-pay patient (you just can’t file Midi claims). And if you don’t use insurance, Midi’s self-pay visits run about $250 for the first visit and $150 for follow-ups— much more than a one-time Sesame visit.
So Midi is not the cheapest route for an uninsured reader. But for someone with PPO insurance, the picture flips: your visit may cost only a copay, the medicine is the cheap generic at your pharmacy, and you get a menopause-trained clinician who manages your care over time. If you’re on Medicare or Medicaid, or paying fully out of pocket, the Sesame-plus-cash-pharmacy route above will almost always cost you less.
See our full Midi Health review for detail on state availability, insurance network, and what a visit covers.
Prefer everything handled in one place? Flat-fee programs (Hers and Winona)
A flat-fee program bundles the clinician, the prescription, and shipping into one monthly price — Hers menopause medication starts around $79/month, and Winona’s progesterone starts around $39/month.You pay more than the bare generic, but you don’t juggle coupons and pharmacy runs, and the fee includes ongoing provider access. This is about convenience and managed care, not the lowest price.
Hers (affiliate)
Hers offers standard prescription hormone therapy — like estradiol and oral progesterone — when appropriate, through an app with provider support. Its menopause oral medication starts at about $79/month on a 12-month plan, and estradiol patches start around $134/month. Good fit if you want everything in one place and you’re fine paying for that convenience.
Winona (affiliate)
Winona is a women’s-only menopause telehealth service with bioidentical progesterone capsules from about $39/month, including unlimited provider messaging and free shipping. Two practical things to know before you choose it: the capsules contain peanut oil, and Winona can’t bill insurance— though you can use an HSA/FSA card. If you ask Winona to send your prescription to an outside pharmacy instead of using its own, a $50/month platform fee applies on top of the medication.
The bottom line on subscriptions:if your only goal is the lowest price for progesterone, none of these is it — the generic at a cash pharmacy costs a fraction of $39 to $99 a month. These programs are worth it only if you value having one team manage everything for you.
Frequently asked questions
- How much is progesterone without insurance?
- Generic micronized progesterone usually costs about $11 to $18 for a 30-day supply with a free coupon, and as little as roughly $8 a month on a larger supply. Brand-name Prometrium can cost around $496 for a single month of the same active medicine.
- What is the cheapest progesterone without insurance?
- For most people with a prescription, the cheapest option is generic micronized progesterone from a flat-rate mail pharmacy like Marley Drug (about $7.67 per month on a 12-month supply) or Cost Plus Drugs, or with a GoodRx or SingleCare coupon. If you do not have a prescription, a one-time online visit from about $37 plus a generic fill is the cheapest legal route.
- Can I get progesterone without a prescription?
- No. Progesterone is prescription-only in the US, and over-the-counter progesterone cream is not the same prescription medicine. A low-cost telehealth visit is the fastest way to get a prescription. Because progesterone is not a controlled substance, a licensed clinician who can treat you in your state can prescribe it after an evaluation.
- Is generic progesterone the same as Prometrium?
- Yes. It is the FDA-approved generic of Prometrium, with the same active ingredient, dose, and capsule form, held to the FDA's equivalence standard. The main difference is the price.
- Is Cost Plus Drugs or Marley cheaper for progesterone?
- Both are low. Cost Plus lists 100 mg progesterone at about $9.45 for 30 capsules plus shipping. Marley Drug charges $14.50 per month on a 3-month supply, or $92 for a full year of 360 tablets, which is about $7.67 per month, with free delivery. The trade-off is mail delivery instead of same-day pickup.
- Is progesterone cheaper with GoodRx?
- A GoodRx or SingleCare coupon can drop a high retail quote to around $18 for 30 capsules of 100 mg, or about $33 for 90. The price varies by pharmacy and ZIP code, so check it for your location.
- Is oral progesterone cheaper than progesterone cream or inserts?
- Usually yes. Generic oral capsules are the lowest-cost form for hormone therapy. Vaginal inserts and compounded creams are often far more expensive and are used for different situations.
- Why did my pharmacy quote me hundreds of dollars?
- You were likely quoted the full retail price or the brand-name Prometrium price. Ask the pharmacist to run the generic with a free coupon and compare it to a mail-order pharmacy. The same active medicine is usually a small fraction of that quote.
- Is compounded progesterone FDA-approved?
- No. Compounded progesterone is custom-mixed by a compounding pharmacy and is not FDA-approved, so the FDA does not verify its safety, effectiveness, or quality before it is sold. Major medical groups recommend FDA-approved options when one exists.
- Is a 90-day supply of progesterone cheaper?
- Usually yes. If your dose is stable and your clinician agrees, buying a 90-day or longer supply almost always lowers the per-capsule cost.
- Can I use my HSA or FSA for progesterone?
- Generally yes. Prescription progesterone is an eligible expense for HSA and FSA accounts, and most telehealth visits are too. Keep your receipt for reimbursement.
- Do I need progesterone if I take estrogen?
- Often, but not always. If you have a uterus and take systemic estrogen, a progestogen is usually added to help protect the uterine lining. People without a uterus, or those using only certain low-dose vaginal estrogen, may have different needs. Ask your clinician.
- Can I switch pharmacies after my progesterone prescription is sent?
- Yes. You can ask your clinician or pharmacy to transfer the prescription to a cheaper pharmacy, including a mail-order option.
- What is the cheapest way to get progesterone if I need a new prescription?
- A one-time, low-cost telehealth visit to get evaluated and prescribed, then filling the generic at a cash pharmacy. That is roughly $37 once, then about $8 to $18 a month.
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Take the free 60-second matching quiz →Keep reading: Best online HRT providers · HRT cost in 2026 · FDA label changes 2026 · How we verify prices