Progesterone Pills Online: What They Cost and the Smartest Way to Get a Prescription in 2026
By The HRT Index Editorial Team · Last verified:
Some links below are affiliate links. If you start care through one, we may earn a commission at no extra cost to you. It never changes our picks. We rank by fit, cost, and whether the prescription is legitimate, not by who pays us. Full disclosure.
You can get progesterone pills online, and it’s completely legitimate — as long as a licensed clinician reviews your health history and sends the prescription to a pharmacy. Here’s the part almost nobody says out loud: the pill itself is cheap. Generic micronized progesterone often costs under $20 a month, and as little as about $8 a monthon a larger supply. So the real question isn’t where to buy it. It’s which route gets you the prescription without overpaying for the visit.
For most people with PPO insurance, Midi Health is the best overall route — it takes insurance and sends a real, FDA-approved prescription to your local pharmacy. Want the lowest cost with no subscription? Sesame. Want a menopause specialist managing your whole plan, shipped to your door? Winona.You can’t buy progesterone over the counter — it’s prescription-only — and if you have a peanut allergy, you’ll need a peanut-free version. We’ll show you exactly how to get one.
| If you want… | Best pick | What it costs | Why |
|---|---|---|---|
| Insurance to help + ongoing care | Midi Health ⭐ | Your plan’s copay; $250 first / $150 follow-up self-pay | FDA-approved Rx to your pharmacy, all 50 states |
| Cheapest path, no subscription | Sesame | One-time visit often ~$35; pill ~$10–$20/mo at pharmacy | New Rx sent to your own pharmacy, same day |
| A specialist to manage everything | Winona | From $39/mo, shipped | Menopause-focused care, no pharmacy run (compounded — see below) |
| A familiar all-in-one brand | Hers | Oral meds from $79/mo (12-mo plan) | Bundled menopause care |
| Just a cheaper refill (you already have an Rx) | Cash pharmacy | ~$8–$20/mo | No new visit needed — just the cheapest fill |
Not sure which one is you? → Take our free 60-second matching quiz.
Find my route in 60 seconds →✅ What we actually verified for this guide
- Pharmacy prices. Current cash and coupon prices for generic progesterone and brand Prometrium from GoodRx, SingleCare, Drugs.com, and Marley Drug (June 2026).
- The medicine itself. FDA-approved uses, dosing, side effects, and the peanut-oil warning against the official FDA/DailyMed label for Prometrium.
- The 2026 FDA change. February 12, 2026 removal of the boxed warning (naming Prometrium) confirmed against the FDA’s own announcement.
- Each provider. Visit cost, prescription type (FDA-approved vs. compounded), pharmacy routing, insurance, and state coverage on their own live pages — including Winona’s own help center on FDA approval.
No fake reviews. No invented medical reviewer. Sources at the bottom; prices re-checked regularly.
Can you get progesterone pills online?
Yes. You can get progesterone pills online through a legitimate prescription process — but not by skipping the doctor. A licensed clinician has to review your symptoms and history and decide progesterone is right for you, then send the prescription to a pharmacy. Mayo Clinic states plainly that progesterone is available only with a doctor’s prescription.
Here’s what the real, safe path looks like:
- 1You fill out an online intake or book a video visit.
- 2A licensed provider reviews your history, medications, and risks. They may prescribe progesterone, suggest a different form, ask for more information, or decline.
- 3If it's appropriate, the prescription goes to a pharmacy — your local one for pickup, or an online one for delivery.
“Online” doesn’t mean “no prescription.” It means the medical visit happens over your phone or laptop instead of in a waiting room. That’s it.
⚠ One hard rule
Walk away from any site that sells prescription progesterone with no clinician review. A real provider sometimes says no — and that’s a feature, not a bug. It means someone is actually checking that this is right for you. A site that hands out hormones to anyone with a credit card is the one to worry about.
Not sure whether you need a provider, a refill, or a full plan?
Take the free 60-second matching quiz →How much do progesterone pills cost online?
The medicine is cheap — often under $20 a month for the generic — but your total online cost depends on whether you’re paying for a visit, a membership, shipping, or just the pill. A low drug price and a low first-month cost are not the same thing. See our full HRT cost guide for broader context.
What progesterone actually costs at the pharmacy
Generic micronized progesterone is one of the more affordable prescriptions out there. With a free discount card, it’s usually in the low double digits — and a longer supply pushes it lower.
| What you’re buying | Cash retail (no coupon) | What we found with a coupon |
|---|---|---|
| Generic, 100 mg, 30 capsules | ~$60 | from ~$12–$16 (GoodRx, Drugs.com) |
| Generic, 100 mg, 90 capsules | ~$422 | ~$33 with SingleCare (≈ $11/month) |
| Generic, 100 mg, 12-month supply | — | $92 at Marley Drug (≈ $8/month) |
| Brand-name Prometrium, 100 mg, 90 capsules | ~$422 average retail | Coupons cut the price, but still far higher than generic |
The takeaway: the generic is cheap, the brand is not, and a discount price can beat a subscription’s pill cost — sometimes even your insurance copay.
Our honest admission
Progesterone pills online are usually NOT the cheapest way to buy the medicine itself. If you already have a valid prescription, a cash pharmacy will beat almost every telehealth program on the pill price alone.
But that’s not the whole story. You can’t legally write your own prescription. What you’re paying a telehealth service for is the part you genuinely can’t do yourself: a licensed clinician deciding it’s right for you, handling the prescription, and being there for follow-up.
- Already have a prescription? Skip the paid visit. Compare cash pharmacies and discount cards above.
- Need a new one? Then “cheapest” has to include the visit — that’s where the routes below come in.
Every route, side by side
Progesterone pills online — every route compared (2026). Prices verified June 9, 2026; checkout totals can change.
| Route | How it works | Visit cost | Pill cost | FDA-approved? | To your pharmacy? | Insurance? | Best for |
|---|---|---|---|---|---|---|---|
| Midi Health ⭐ | Ongoing clinical care | Copay if insured; $250 first / $150 follow-up | ~$8–$20/mo at pharmacy | ✅ FDA-approved capsules | ✅ Yes | ✅ Most PPOs; not Medicaid/Medicare | Insured patients + ongoing menopause care |
| Sesame | One-time visit | Often ~$35 (shown before you book) | ~$10–$20/mo at pharmacy | ✅ FDA-approved generic | ✅ Yes | Mostly cash | Lowest cost, no subscription |
| Winona | Subscription | Free intake | From $39/mo, shipped | ⚠ Compounded (503A pharmacy — not FDA-approved finished drug) | ❌ Ships to you | ❌ No; HSA/FSA ok | Specialist managing everything; peanut-free option available |
| Hers | Subscription | Included | Oral from $79/mo (12-mo plan) | Confirm at pharmacy | ❌ Ships to you | ❌ No | Familiar bundled brand |
| Cash pharmacy | You already have an Rx | None | ~$8–$20/mo | ✅ FDA-approved generic | ✅ Yes | Cash/coupon | Cheapest refill if you already have a prescription |
| Alloy(not our affiliate) | Subscription | ~$50 to start | Progesterone $23/mo; free with estradiol | ✅ FDA-approved daily pill | ❌ Ships to you | HSA/FSA | If you need estrogen AND progesterone together |
⭐ = our pick for most people. We include Alloy (non-affiliate) to keep ourselves honest — a page worth trusting tells you about a good deal even when we don’t earn from it.
We’ll map your best route based on your insurance, state, and budget.
Take the 60-second matching quiz →Best places to get progesterone pills online in 2026
The “best” place depends on one thing: what matters most to you — insurance, lowest cost, a specialist, or pure convenience. Midi is the strongest all-around route (especially if you’re insured), Sesame is the cheapest no-subscription path, Winona is the easiest specialist-led option, and a regular pharmacy wins on price if you already have a prescription.
Midi Health — best overall, and best if you have insurance
⭐ Our top pickMidi is our top pick for most people because it does the thing that makes progesterone affordable: it prescribes FDA-approved progesterone capsules and sends them to your local pharmacy, where you pay the cheap generic price. And it takes insurance for your visits. Midi is available in all 50 states, its clinicians focus on menopause, and your clinician decides whether you need any testing to start.
Self-pay visits run $250 for the first and $150 for follow-ups. Midi is in-network with most PPO plans (coverage and copays vary by plan). Midi also offers a separate compoundedprogesterone through its online store — made vegan and peanut-free — for people who need to avoid those ingredients. That’s a real plus for allergy sufferers — just know it’s a separate, out-of-pocket, compounded product, not the FDA-approved one filled at your pharmacy.
- ✓ FDA-approved Rx sent to your local pharmacy — you pay generic price
- ✓ In-network most PPOs; all 50 states; HSA/FSA accepted
- ✗ Cannot bill Medicare; cannot treat Medicaid/Medi-Cal patients at all (not even as cash patients)
“Midi was so easy: I got a same day appointment and they took my insurance.”
“I signed up and had a visit the next day. My clinician was kind and thoughtful. By the end of the day, I had my prescriptions called in.”
Provider-published reviews, Midi Health. Individual experiences only — not guaranteed results, and not a medical claim.
Sesame — cheapest route with no subscription
Sesame is the best fit if your goal is a legitimate new prescription at the lowest total cost.You book a one-time visit — often same-day, and you see the price before you book (frequently around $35) — a licensed provider reviews you, and if it’s appropriate, they send a progesterone prescription to the pharmacy of your choice. There’s no membership and no recurring fee. You then fill the standard FDA-approved generic with insurance or a coupon.
This is the route for cost-conscious shoppers, people who are uninsured but price-shopping, and anyone on Medicare who can fill the cheap generic on a Part D plan after a quick visit.
- ✓ See the price before you book; often ~$35; no membership
- ✓ FDA-approved generic sent to your local pharmacy
- ✓ Good option for Medicare patients (use Part D for the cheap generic)
Winona — best specialist-led, all-in-one option
Winona is the simplest path if you’d rather have menopause-focused specialists manage everything and ship it to your door. Its progesterone capsule starts at $39 a month — no separate pharmacy trip — with free standard shipping, board-certified doctors who focus on menopause, and ongoing messaging. It accepts HSA/FSA. It does not bill insurance.
Important: Winona’s progesterone is compounded, not FDA-approved
Winona makes its hormones at its own licensed 503A compounding pharmacies. In Winona’s own words, “since these pharmacies aren’t regulated by the FDA, Winona’s treatments are not FDA approved”— even though they’re made from FDA-approved ingredients (which is notthe same as an FDA-approved finished medicine). Winona’s product page does call the capsule “FDA-approved,” so this is a genuine contradiction worth knowing before you choose it for that reason.
Winona does NOT dispense the FDA-approved generic you’d get at a regular pharmacy. If having the standard, FDA-approved pill specifically matters to you, Midi or Sesame are the better fit. Winona’s capsules also contain peanut oil— skip to the peanut-free section if that applies to you. But because Winona is specialist-led and can compound a custom or peanut-free formula, it’s a strong pick for women who want one service running the whole plan with no pharmacy juggling.
Hers — familiar, bundled, brand-name comfort
Hers is a solid secondary option if you already trust the brand and want everything in one familiar app. Oral progesterone starts at $79 a month on a 12-month plan, delivered if prescribed after a consultation. Insurance isn’t required. It’s the priciest monthly option here and isn’t available in every state — but the experience is smooth and recognizable. Confirm the exact product you’re prescribed at the pharmacy.
Cheapest of all — if you already have a prescription
If a doctor already prescribed progesterone and you just want it cheaper, you don’t need to pay for another visit. Compare cash prices at regular and mail-order pharmacies with a free discount card. Generic progesterone commonly lands around $8–$20 a month this way.
Compare prices on GoodRx →Honest benchmark (not our affiliate): Alloy
If you need estrogen and progesterone together, Alloy is worth a look: progesterone at $23/mo on its own, and free when you also get an estradiol prescription. Describes its progesterone as a bioidentical, FDA-approved daily pill, shipped to your door, HSA/FSA eligible. Not in our affiliate stack, but worth knowing.
See Alloy →FDA-approved progesterone pills vs. compounded progesterone: what’s the difference?
FDA-approved oral micronized progesterone (brand name Prometrium, plus its generic) is a finished drug the FDA reviewed for safety, quality, and effectiveness. Compounded progesterone is custom-mixed by a pharmacy and is not FDA-approved — though it has real, legitimate uses, like making a peanut-free capsule. For a standard progesterone pill, the FDA-approved version is the default; compounded is the exception for a specific reason.
- ✓Micronized progesterone — progesterone ground into tiny particles so your body can absorb it as a pill. It’s “bioidentical” — chemically identical to the progesterone your ovaries make. FDA-approved brand is Prometrium; the FDA-approved generic is rated as therapeutically equivalent — same active ingredient, same dose, far lower price. That rating applies to FDA-approved generics only — never to compounded products.
- ⚠Compounded progesterone — progesterone mixed to order by a compounding pharmacy (often a 503A pharmacy). The FDA does not review compounded drugs before they reach you.
What ACOG says
The American College of Obstetricians and Gynecologists (ACOG) advises that compounded “bioidentical” hormone therapy should not be prescribed routinely when an FDA-approved version exists, and that patients should be told these products lack FDA approval. For most people, the FDA-approved generic is the smarter, cheaper, better-studied place to start.
When compounded genuinely makes sense:if you need a dose that isn’t sold commercially, or you have to avoid peanut oil or gelatin for an allergy or a vegan diet. Those are real medical reasons — not a marketing upgrade.
| Provider / product | What their page says | What we verified | How to treat it |
|---|---|---|---|
| Midi — capsules to your pharmacy | FDA-approved, sent to your pharmacy | Standard FDA-approved generic, filled at a normal pharmacy | FDA-approved ✅ |
| Midi— “Progesterone” store product | Compounded; vegan, peanut-free | Compounded; out-of-pocket only | Compounded ⚠ |
| Winona — progesterone capsule | Product page says “FDA-approved” | Winona’s own help center says its treatments are not FDA-approved (made at its 503A compounding pharmacies) | Compounded — not FDA-approved ✗ |
| Hers — oral progesterone | Offered after a consult | Confirm the dispensed product at the pharmacy | Verify at pharmacy |
| Alloy (non-affiliate benchmark) | “Bioidentical, FDA-approved daily pill” | FDA-approved generic; free with estradiol or $23/mo on its own | FDA-approved ✅ (benchmark) |
The line we won’t cross: we never call a compounded product “FDA-approved,” and we never claim it’s “clinically proven” the way a finished, FDA-approved drug is. Being made from FDA-approved ingredients does not make the final compounded medicine FDA-approved. See our compounded vs. FDA-approved HRT guide for the full explainer.
Can you buy progesterone pills over the counter?
No. Progesterone pills are prescription-only in the United States — you cannot buy them over the counter. A licensed clinician has to review your history and write the prescription first; Mayo Clinic confirms progesterone is available only with a doctor’s prescription. The good news is the “doctor” part can happen entirely online.
If a website offers prescription progesterone capsules with no medical review at all, treat that as a red flag and walk away. Over-the-counter “progesterone creams” sold as supplements are a different, unregulated product and aren’t what this page is about.
Progesterone pills vs. cream: which one fits your search?
If you searched for progesterone pills,you’re looking for the oral capsule— the most common form, taken once a day. Progesterone also comes as a body cream and a vaginal cream, and those can be legitimate for some people, but they’re not interchangeable with the pill.
- →Oral capsule (the pill). What most people mean, and what FDA-approved Prometrium and its generic are. The focus of this page.
- →Compounded progesterone cream or capsule. Custom-mixed; useful for allergies (peanut-free) or special doses, but not FDA-approved.
- →Vaginal cream. A compounded cream — not a pill. Fine if a cream is genuinely what you want, but it doesn’t match a “progesterone pills” search.
Torn between a pill and a cream? Our quiz factors it in.
Take the quiz →Do you actually need progesterone with estrogen?
If you still have your uterus and take systemic estrogen, you’ll almost always need progesterone too— to protect the lining of your uterus. Estrogen on its own can thicken that lining and raise the risk of endometrial (uterine) cancer, and progesterone keeps it in check. If you’ve had a hysterectomy, you usually don’t need progesterone for that reason. Your clinician makes the final call based on your history.
Progesterone vs. progestin — they’re not the same
Progesterone is the bioidentical hormone (like Prometrium). A progestinis a synthetic lab-made cousin (like medroxyprogesterone, or the hormone in a Mirena IUD). Both can protect the uterine lining, but they’re different molecules with different feels and side effects. If you searched “progesterone pills,” you’re after the bioidentical pill — not a progestin.
Continuous vs. cyclic — your doctor decides
You might take progesterone every night (continuous), or only part of each month(cyclic), depending on your situation. Both schedules are normal, and the choice affects whether you have a monthly bleed. The dose is also your clinician’s job — not something to decide from a webpage.
Already on estrogen and need to add progesterone? Check your covered options on Midi.
Check Midi coverage →Side effects, peanut oil, and the practical stuff to ask about
Common progesterone side effects include drowsiness, breast tenderness, bloating or cramps, headaches, mood changes, nausea, and some irregular bleeding or spotting.The single biggest safety detail: standard Prometrium contains peanut oil, so it’s not for anyone with a peanut allergy. Always tell your provider your full history before you start.
Why it can make you sleepy (and why that’s useful)
Progesterone is usually taken at bedtime.Your body turns it into a calming compound, so it can make you drowsy or a little dizzy — which is welcome at 10 p.m. and not great if you’re driving at 10 a.m. Many people find it actually helps them sleep. If the capsule is hard to swallow, take it standing up with a full glass of water. Tell your provider about anything that feels severe or doesn’t settle.
The peanut-oil problem — and the peanut-free fix
Prometrium uses peanut oilas an inactive ingredient, which can be dangerous for someone with a peanut allergy. But you have options — a peanut allergy doesn’t have to be the end of the road. It usually just means the standard capsule is out, and you can ask your clinician or pharmacist about a peanut-free option.
| Product | Peanut oil? | Gelatin? | Vegan option? |
|---|---|---|---|
| Prometrium (FDA-approved) | Yes | Yes (softgel) | No |
| Generic micronized progesterone | Often yes — ask pharmacist to check specific product | Usually | Varies |
| Winona capsule | Yes | Yes | No (standard; custom available) |
| Midi compounded progesterone | Made peanut-free | No | Yes |
| Compounded (local pharmacy) | Can be made peanut-free | Can be gelatin-free | Yes, on request |
The practical move: ask the pharmacist to check the inactive ingredients of the specific product before you fill it, and if you need peanut-free, ask about a compounded version (Midi offers one, and local compounding pharmacies do too). If you’ve ever been told you “can’t take progesterone” because of a peanut allergy, it’s worth a second conversation — you may simply need a different formulation.
Need peanut-free or vegan? Flag it in the quiz and we’ll point you to a peanut-free path.
Take the quiz →Who should NOT use online-only care for progesterone
Online care fits stable, straightforward situations. A good provider will tell you to be seen in person if any of these apply. Be upfront with your clinician if you have:
| Situation | Why it matters |
|---|---|
| Undiagnosed abnormal vaginal bleeding | Needs to be checked before any hormone |
| Current, suspected, or past breast cancer (or other hormone-sensitive cancer) | May be a contraindication — specialist review required |
| History of blood clots, pulmonary embolism, stroke, or heart attack | Prometrium label lists these among its warnings |
| Liver disease or another major medical condition | Should be discussed with a specialist first |
| Pregnancy or possible pregnancy | Not appropriate for menopause HRT protocols |
| Severe or sudden symptoms, or a complicated medication picture | Needs hands-on evaluation — not appropriate for online-only care |
Not sure you’re a clean fit for online-only care? The quiz routes you to an in-person option when that’s the right call.
Take the quiz →Bring this to your visit
Whatever route you choose, have answers to these ready:
- 1Do you still have your uterus?
- 2Are you taking systemic estrogen — and which kind and dose?
- 3Any abnormal bleeding?
- 4Any breast, uterine, ovarian, or endometrial cancer history?
- 5Any blood clot, stroke, heart attack, liver, or gallbladder history?
- 6Peanut allergy? Vegan or gelatin concerns?
- 7All current medications and supplements?
- 8Any past reaction to progesterone or progestins?
Will insurance, Medicare, or Medicaid cover progesterone pills online?
Generic micronized progesterone is covered by most insurance plans and Medicare Part D, and it’s cheap with a coupon if you’re uninsured — but the online visit is a separate question. Whether a telehealth visit is covered depends on the provider and your plan.
- ✓PPO insurance: Midi is in-network with most PPO plans and bills insurance for visits; you pay your usual copay, and the generic is filled at your pharmacy. Coverage and copays vary by plan.
- ⚠Medicare: Midi can’t bill Medicare. But generic progesterone is covered on most Part D plans — so the simple route is a quick visit (Sesame, or your own prescriber) and then fill the cheap generic on your Part D plan.
- ✗Medicaid or Medi-Cal: Midi cannot treat you, even as a cash patient. A one-time visit elsewhere plus your own pharmacy, or a local in-person clinic, is the better path.
- $Uninsured: the cheapest combo is a low-cost one-time visit (often around $35 at Sesame) plus the generic with a coupon — frequently $8–$20 a month.
Insured and want it covered?
Check whether Midi takes your plan →How the online prescription process actually works
The big fork in the road is right at the start: do you need a brand-new prescription, or just a cheaper fill of one you already have? Sort that first and everything else falls into place.
- 1Confirm what you need. New prescription → a provider route (Midi, Sesame, Winona, Hers). Just a refill → a cash pharmacy. Complex history or red flags → in-person care. Unsure → the quiz.
- 2Ask for pills, specifically. If you want the oral capsule, say so during intake — not a cream.
- 3Let the clinician review. They may prescribe, suggest a different form, request more information, or decline. All of that is normal.
- 4Choose pickup or delivery. Sesame and Midi can send your prescription to your local pharmacy. Winona and Hers ship to your home.
- 5Plan for follow-up. Subscriptions like Winona include ongoing messaging and refills; with a one-time visit, you arrange refills as needed.
That’s the whole thing. No mystery, no gray market — just telehealth doing what a clinic does, faster.
How we picked these routes
We compared every option on the things that actually change your decision — total cost (visit plus pill), whether it’s FDA-approved or compounded, insurance, pharmacy routing, state coverage, and lab requirements — and we checked the medical facts against the FDA label and official guidance. We rank by fit and evidence, not by who pays us. On a prescription-pill page, the cleanest, cheapest, most accessible FDA-approved route wins — even when that means sending you to a cash pharmacy or a provider we don’t earn from (Alloy).
We re-check pricing, state rules, and FDA status on a regular schedule, and we date every update so you know how fresh it is. For the wider landscape, see our guide to the best online HRT providers for menopause.
Last verified: . Last updated: . We verified public pricing, prescription routes, FDA-approved vs. compounded status, and safety details from provider pages, pharmacy pricing tools, the FDA, DailyMed, Mayo Clinic, and ACOG. Checkout prices and state availability can change. This guide is general information, not medical advice — talk with a licensed clinician about your situation.
Progesterone pills online — FAQ
- Can I buy progesterone pills online without a prescription?
- No. Oral progesterone capsules are prescription-only in the U.S. A legitimate online route still requires a licensed clinician to review your history and write a prescription. Avoid any site offering them with no medical review.
- What is the cheapest way to get progesterone pills online?
- If you already have a prescription, a cash pharmacy with a free discount card is usually cheapest — often $8 to $20 a month. If you need a new prescription, include the visit cost; a one-time visit through Sesame plus a generic fill is typically the lowest total, while insured patients often do best with Midi.
- Are progesterone pills FDA-approved?
- Yes — FDA-approved oral micronized progesterone exists (brand Prometrium and its generic). But not every progesterone product sold through telehealth is an FDA-approved finished drug; compounded versions are not FDA-approved.
- Is compounded progesterone the same as FDA-approved progesterone?
- No. Compounded progesterone is custom-mixed and not FDA-approved; the FDA does not check its safety, quality, or effectiveness before sale. It has legitimate uses such as peanut-free formulas, but it is not interchangeable with an FDA-approved pill, and being made from FDA-approved ingredients does not make the finished product FDA-approved.
- Do I need progesterone if I take estrogen?
- If you still have your uterus and take systemic estrogen, a progestogen is generally recommended to protect the uterine lining and lower cancer risk. After a hysterectomy you usually do not. Your clinician decides what is right for your history.
- Can progesterone pills make you tired?
- Yes, they can cause drowsiness, which is why they are usually taken at bedtime. Do not drive or do anything risky until you know how it affects you, and never change or stop hormone therapy without talking to your provider.
- What if I am allergic to peanuts?
- Standard Prometrium contains peanut oil and is not safe for people with a peanut allergy. Ask the pharmacist to check the specific product, and ask your clinician about a peanut-free option such as a compounded capsule. A peanut allergy usually means you need a different formulation, not no treatment.
- Is progesterone a controlled substance?
- No. Progesterone is not a controlled substance, unlike testosterone. That tends to make it simpler to prescribe through telehealth, though availability still depends on the provider, your state, and the pharmacy.
- Did the FDA change anything about progesterone in 2026?
- Yes. On February 12, 2026, the FDA removed its boxed warning about heart disease, breast cancer, and dementia from several menopause hormone products, and Prometrium (oral progesterone) was one of them. The FDA kept a separate endometrial cancer warning only on estrogen-alone products.
Sources
Medical & regulatory
- FDA — Labeling Changes for Menopausal Hormone Therapy Products (boxed-warning removal, Feb 12, 2026)
- DailyMed (NIH) — Prometrium (progesterone, USP) label — peanut-oil warning; uses; side effects
- Mayo Clinic — Progesterone (oral route) — prescription-only; uses; bedtime dosing
- ACOG — Compounded Bioidentical Menopausal Hormone Therapy (Clinical Consensus No. 6)
- FDA — Compounding and the FDA: Questions and Answers
Pricing
- GoodRx — Progesterone / Prometrium prices
- SingleCare — Progesterone price & coupons; Drugs.com — Progesterone price guide; Marley Drug — Progesterone
Providers
- joinmidi.com (HRT, pricing & insurance, compounded progesterone store page); bywinona.com + help.bywinona.com (progesterone capsule page + “Are Winona’s treatments FDA approved?” help article); sesamecare.com (progesterone / Prometrium prescriptions); forhers.com (menopause care); myalloy.com (progesterone pills)
Also see: Micronized progesterone online · Best online progesterone providers
Still deciding which HRT program is right for you?
Answer a few quick questions — whether you need a new prescription or a refill, your insurance, your state, any peanut allergy, and whether you want a specialist or the lowest price — and we’ll map your best route and the questions to ask before you start.
Take the free 60-second matching quiz →The HRT Index is an independent comparison resource for HRT telehealth providers. This article is for general education and is not medical advice. Talk to a licensed clinician about whether progesterone pills are appropriate for you. See also: Micronized progesterone online · Best online progesterone providers · Best HRT telehealth providers