EstroGel Reviews: What Women Report, What the Label Shows and Real-World Tips

By The HRT Index Editorial Team · Editorial research — not medically reviewed · Last verified October 2026

EstroGel reviews are surprisingly hard to find. When we checked on October 31, 2026, Drugs.com had none, and only 12 of the 772 reviews we read on WebMD's shared estradiol skin-product page mentioned EstroGel. Most were positive about sleep and hot flashes. The complaints were breast tenderness, headaches, nausea and hair loss.

The HRT Index is the independent decision resource for online menopause and HRT care — comparing telehealth providers on clinical legitimacy, care quality, medication fit, price transparency, and access, with every claim verified and dated, so women can choose the path that fits their situation before their first consult.

What we actually verified · Last verified October 2026

• What we read: the current EstroGel prescribing information and patient information on DailyMed, including its clinical trial, side effect and absorption data; the Drugs.com EstroGel listing; all 772 reviews we could load from WebMD's estradiol transdermal review page, which pools EstroGel with patches and other gels, searched one by one for EstroGel and Oestrogel; the Drugs.com Divigel and Elestrin review pages for comparison; the Divigel and Elestrin labels and a generic estradiol gel 0.06% label on DailyMed; The Menopause Society's 2022 hormone therapy position statement; MedlinePlus patient information on topical estradiol; and the FDA's November 2025 request to change menopause hormone therapy labels, its February 2026 approval announcement and its list of updated labels. Every source is listed at the bottom with the date we read it.
• What we did not do: we did not use EstroGel ourselves, contact reviewers, examine anyone or speak with a clinician for this page. We didn't write or edit any review, and we don't publish star ratings of our own. This is editorial research, not medical review, and not advice for your situation.
• Commercial interest: The HRT Index may earn a commission from some providers featured through The HRT Index's Find My HRT Path tool. No drug maker or provider paid for this page or reviewed it, and we don't earn anything from EstroGel sales. See our affiliate disclosure.
• Verification Standard: we judge online menopause care on five pillars, in this order: clinical legitimacy, care quality, medication fit, price transparency and access. Our methodology explains how.

Jump to: Scorecard · What it is · What reviews say · Does it work? · Side effects · Applying it · Dose and pumps · Bleeding and progesterone · Boxed warning and FDA changes · Who shouldn't use it · Cost and generics · How it compares · Who tends to do well · Questions to ask · Online care · FAQ · Sources

EstroGel reviews at a glance: the scorecard

Here's the short version, built from the review data we fetched on October 31, 2026 and from the FDA label. We don't give EstroGel a score of our own. Reviews are personal, unverified reports, so we treat them as a guide to what to ask about rather than proof of what will happen to you.

What EstroGel is, in plain terms

EstroGel 0.06% is a clear, alcohol-based estradiol gel made by ASCEND Therapeutics. Estradiol is the main estrogen your ovaries make before menopause. The gel goes on your skin once a day, and the estradiol is absorbed into your bloodstream.

According to the FDA label, EstroGel is approved for two uses:

• Moderate to severe hot flashes and night sweats (the label calls them vasomotor symptoms) due to menopause
• Moderate to severe vulvar and vaginal atrophy due to menopause, such as dryness, irritation and pain with sex. For vaginal symptoms alone, the label says clinicians should first consider products used in the vagina, like vaginal estrogen.

A few practical facts from the label shape almost every review:

• One pump is one dose. Each full press of the pump gives 1.25 grams of gel containing 0.75 mg of estradiol.
• It goes on one arm. You spread it thinly over the whole arm, inside and outside, from wrist to shoulder.
• It's systemic. Unlike vaginal estrogen, EstroGel is meant to raise estrogen levels through your whole body. That's why it carries the same kinds of warnings as estrogen pills and patches.
• It skips the liver's first pass. Estrogen absorbed through skin doesn't pass through the liver first the way a pill does. The label says the clinical significance of this hasn't been determined.
• It has a short ingredient list. Estradiol, purified water, alcohol, triethanolamine and carbomer 974P.

Outside the U.S., the same type of product is sold under the name Oestrogel, and two of the reviews we found used that name. EstroGel is a different product from Divigel (a 0.1% gel in single-dose packets for the thigh) and Elestrin (another 0.06% pump gel with a smaller dose per press, for the upper arm). Our EstroGel vs Divigel comparison goes through the differences.

What EstroGel reviews say: patterns from a small set of real reports

Here's the honest finding: there just aren't many EstroGel-specific reviews online, so be careful with any page that offers a confident average.

• Drugs.com had an EstroGel listing with no user reviews when we checked on October 31, 2026. It invited readers to "be the first to share your experience." Drugs.com's EstroGel comments link sends you to a broader estradiol topical page that's mostly about vaginal products, so we didn't use that rating for EstroGel.
• WebMD has one review page titled "Estradiol transdermal (Climara, Divigel, Dotti, Elestrin, EstroGel, Evamist, Lyllana, Menostar, Minivelle, Vivelle-Dot)." It showed an overall rating of 3.5 out of 5 from 775 reviews. That number covers patches, sprays and gels together, and most reviews we read were about patches. It isn't an EstroGel rating.

So we did the slow version. We loaded the 772 reviews WebMD displayed, sorted by most recent, and read every one that named EstroGel or Oestrogel. We found 12:

• 11 describe the reviewer's own use of EstroGel or Oestrogel.
• 1 is a review of Divigel in which the reviewer says EstroGel worked "very well" for her before.
• They span August 2008 to August 2026. Ten of the 12 reviewers said they were 45 to 64 years old.
• Eight of the 11 EstroGel users rated it 4 or 5 out of 5. Two rated it below 3 and stopped using it.

This is a small, self-selected group. People with strong experiences, good or bad, are the ones who post. Reviewers don't have to prove what they used, and star ratings on a shared page can be hard to tie to one product. Treat these reports as examples of what can happen, not as odds.

What we found reading the reviews one by one

What reviewers liked

• Sleep. "Game changer," wrote one woman after three weeks, who said she could "sleep through a night now without sleeping pills." Another said she sleeps through the night and has more energy after a month. A third, using Oestrogel, said she was sleeping better.
• Hot flashes and night sweats. "No hot flashes at all," wrote a reviewer who had "severe hot flashes day and night." Another said "hot flashes, vaginal dryness and overall moodiness have improved greatly." A woman who has used it since a hysterectomy at 33 said it controls her night sweats, though her mild hot flashes "do not go away."
• Mood and brain fog. Four reviewers described steadier mood. One linked better sleep to "no more brain fog, anxiety, irritability."
• Vaginal symptoms and sex drive. One reviewer said vaginal dryness improved, one said her vaginal tissue had changed, and one said her sex drive was "coming back."
• Long-term use. A woman born without ovaries said she had used EstroGel with progesterone for at least 15 years and called it "excellent" after many other hormone therapies.

What reviewers didn't like

• Breast and nipple tenderness. Two reviewers. For one, the soreness was gone within days. For the other, it came with other side effects and she stopped.
• Headaches. One reviewer, who had a hysterectomy and used two pumps a day, said she developed severe headaches she called migraines, plus hair loss, and that EstroGel "did not help with hot flashes." She said the headaches stopped when she stopped the gel.
• Stomach and gut symptoms. Four reviewers mentioned nausea, stomach pain, bloating or diarrhea. One, who was also taking progesterone, said she had "severe diarrhea" and nausea two weeks in and stopped. Her doctor thought it was a stomach bug, but she believed it was the medicine.
• Fluid retention and aches. One Oestrogel user described nausea, more joint and muscle pain, bloating and fluid retention five weeks in, and said she wasn't sure yet how she felt about it.
• Skin. One reviewer had a slight itch on her arm after applying it that "goes away within the hour."

Off-label use came up once. A transgender woman wrote that she was using EstroGel with spironolactone as part of transition care and reported anxiety attacks, a racing heart and nausea. EstroGel isn't FDA-approved for that use. We include it in the count for completeness, but her experience may not apply to menopause care.

The right online menopause care isn't the same for every woman — it depends on your symptoms, what you've already tried, your age, your state and your health history. Some situations belong with an in-person clinician first. Use The HRT Index's Find My HRT Path tool to explore a featured care option for your situation — and to flag when online care isn't the right starting point — before your first consult.

Find My HRT Path is free, takes about 60 seconds and doesn't ask for your email. It asks about your symptoms, what you've already tried, your age, your state and your health history. It isn't an eligibility test or a diagnosis, and it can't tell you whether EstroGel is right for you.

What reviews of other estrogen gels say

Many more WebMD reviewers on the same page wrote about "the gel" without naming which one. These aren't EstroGel reviews, but they show the practical issues people raise with estradiol gels in general:

• the gel feels sticky, or smells strongly of alcohol
• you have to wait for it to dry before dressing
• the skin where it's applied darkened
• it didn't seem to last a full 24 hours, which one reviewer called a "roller coaster"
• hair loss and acne

Two of these line up with the EstroGel label. Its list of reports since approval includes application site discoloration and alopecia (hair loss). The label notes that because these reports are voluntary, it isn't always possible to tell how often a problem happens or whether the drug caused it.

Does EstroGel work? What the trial found

With so few reviews, the clinical trial in the label is the steadier guide.

Hot flashes

In the trial, 145 postmenopausal women aged 29 to 67 were randomly assigned to one pump (1.25 g) of EstroGel a day or a placebo gel for 12 weeks. Here's what happened to moderate to severe hot flashes:

The difference was statistically significant at weeks 4 and 12, and hot flashes were also less severe on EstroGel. Two things stand out. First, the placebo group improved a lot too, which is common in hot flash studies and one reason single reviews can mislead. Second, by week 12 women on EstroGel averaged under 3 moderate to severe hot flashes a day, not zero. That matches reviewers who said their hot flashes became "mild" rather than gone.

Vaginal symptoms

The label reports a significant increase in mature surface cells in the vaginal lining by week 12 on EstroGel, with no significant change on placebo. That's a sign estrogen is reaching the tissue. If vaginal dryness or painful sex is your main problem, though, vaginal estrogen is usually considered first.

How fast does it work?

In the trial, hot flashes were already significantly lower at week 4, the first point measured. In reviews, women described changes anywhere from about two weeks to a month or more. The label says estradiol levels reached a steady state after about three days of use in a study of a higher dose. Our guide to how long HRT takes to start working explains why symptom relief can take longer than that.

What The Menopause Society says

The Menopause Society's 2022 position statement calls hormone therapy "the most effective treatment" for hot flashes and night sweats. It says that for women younger than 60 or within 10 years of menopause who have no contraindications, the benefits generally outweigh the risks for bothersome hot flashes and preventing bone loss. It also notes that observational studies haven't linked transdermal (through-the-skin) hormone therapy with blood clots, though trials directly comparing it with pills are lacking. Our oral vs transdermal estrogen guide covers this.

EstroGel side effects: what the trial and reviewers report

In two 12-week trials, these were the side effects reported by at least 5% of women on EstroGel:

Application site reactions were reported by 0.6% of women on EstroGel, and itching and rash were also noted.

The patient information lists these as common side effects of EstroGel: headache, breast tenderness or pain, stomach or abdominal cramps and bloating, nausea and vomiting, hair loss, fluid retention and vaginal yeast infection. Those overlap closely with what reviewers described.

The label also lists side effects reported since approval. They include hair loss, application site dryness, pain, discoloration and rash, weight gain, nausea, bloating, diarrhea, dizziness, insomnia, and reports that the drug didn't work or stopped working as well. More serious reports include blood clots, eye blood vessel blockages and severe allergic swelling (angioedema).

When to get help

The patient information says to call your healthcare provider right away if you notice:

• new breast lumps
• unusual vaginal bleeding
• changes in vision or speech
• sudden new severe headaches
• severe pains in your chest or legs, with or without shortness of breath, weakness and fatigue

Call 911 for signs of a stroke, heart attack or a blood clot in the lungs, or for swelling of your face, lips or tongue. For more on side effects that settle and ones that don't, see our HRT side effects guide and signs your HRT dose may be too high.

Applying EstroGel: the practical side reviewers raise

The label has detailed instructions, and a few of them explain common complaints about gels.

• Prime a new pump. Before the first use, press the pump all the way down 5 times and wash that gel down the sink.
• Apply to clean, dry skin on one arm. Spread it thinly from wrist to shoulder, inside and outside. The label says don't massage or rub it in. Don't put it on your breasts or on or in your vagina.
• Let it dry. It dries in 2 to 5 minutes. Wait about 5 minutes before dressing. It's flammable until dry, so avoid fire, flames and smoking.
• Wash your hands with soap and water after applying.
• Apply after bathing. Washing the arm 1 hour after applying lowered average estradiol levels by 22% in a study. If you swim, leave as much time as you can between applying the gel and swimming.
• Watch what goes on top. In a study, putting moisturizer on 1 hour after the gel raised estradiol exposure by 38% and the peak level by 73%. Sunscreen applied 1 hour later lowered both by 16%. Ask your clinician or pharmacist before using lotions or sunscreen on that arm.
• Protect other people. Don't let anyone touch the area for 1 hour, and cover it with clothing. In a study, there was no measurable transfer to another woman after 15 minutes of skin contact 1 hour after applying. MedlinePlus warns that topical estradiol on your skin can harm others, especially men and children, and pets.
• Don't let someone else apply it for you. If someone must, they should wear gloves.
• Count your doses. A 50-gram pump gives 30 daily doses after priming. The label says to throw it away after 30 doses even if it isn't empty, because you may not get the right dose.

If you miss a dose, MedlinePlus says to apply it if your next dose is more than 12 hours away. If it's less than 12 hours away, skip it and go back to your usual schedule. Don't double up. Our how to apply estradiol gel guide walks through technique, and switching from an estradiol patch to gel covers moving between forms.

Reviews that describe a different dose or application site

Several reviews describe EstroGel being used differently from the U.S. label, and it's worth knowing why.

• Two pumps or more. Four reviewers said they used 2 pumps a day, and a UK reviewer used 4 pumps of Oestrogel. The U.S. label says one pump (1.25 g) a day "is the single approved dose," and that the lowest effective dose hasn't been determined.
• Thighs instead of an arm. Two reviewers applied it to their inner thighs, including the UK reviewer. The U.S. label says one arm, wrist to shoulder.

We can't tell from a review where someone lives or what her prescriber intended. Products sold outside the U.S. can come with different directions, and clinicians sometimes prescribe differently from a label. The point for you: follow the instructions you were given, and don't add pumps or move sites on your own. If one pump isn't controlling your symptoms, or you're getting side effects, talk to your clinician. Our guides to HRT dose too low and the HRT equivalent dose chart can help you prepare for that conversation.

Bleeding and whether you need progesterone

EstroGel is estrogen only. If you still have a uterus, estrogen alone raises the risk of endometrial (uterine lining) cancer. The label says adding a progestogen lowers the risk of endometrial hyperplasia, which can come before cancer, and the patient information says adding a progestogen is generally recommended for women with a uterus.

The reviews reflect this. Four of the 11 EstroGel users mentioned taking progesterone or Utrogestan (a UK brand of micronized progesterone) with it. Four said they'd had a hysterectomy, which usually means no progestogen is needed. Our guides to whether you need progesterone if you have a uterus and estrogen-only vs estrogen plus progesterone explain the choices.

Two reviewers described bleeding:

• A woman taking EstroGel with progesterone said her periods, which had stopped for 7 months, came back as regular light periods. A monthly bleed can happen with some combined regimens.
• A woman who had used EstroGel with progesterone for at least 15 years said she was "only now experiencing some irregular bleeding."

The label says abnormal bleeding in postmenopausal women needs proper testing to rule out cancer. If you have new, persistent or unexpected bleeding, tell your clinician. Don't assume it's a normal side effect. See bleeding after starting HRT for what's expected and what isn't.

The boxed warning, and what the FDA's 2025–2026 changes mean for EstroGel

The current label still has the full boxed warning

The EstroGel label on DailyMed (version published June 2026) carries a boxed warning for endometrial cancer, cardiovascular disorders, breast cancer and probable dementia. Those warnings come mainly from the Women's Health Initiative (WHI), a large trial of daily oral conjugated estrogens, with or without medroxyprogesterone acetate, in women aged 50 to 79. The WHI didn't study estradiol gel. The label says the relevance of the WHI findings to other doses, routes and products isn't known, and that without that data the risks can't be ruled out.

What the FDA changed

On November 10, 2025, the FDA asked makers of all menopause hormone therapy to change their labels. In the boxed warning, it asked them to remove the language about cardiovascular disease, breast cancer and probable dementia, and to drop the advice to use the lowest dose for the shortest time. It asked that the endometrial cancer warning stay in the boxed warning for systemic estrogen-alone products like EstroGel. For systemic products, it also asked labels to add that hormone therapy can be considered for moderate to severe hot flashes in women under 60 or within 10 years of menopause, while keeping the heart disease and breast cancer information in the label.

On February 12, 2026, the FDA announced it had approved the first updated labels. When we checked the FDA's list of products with updated prescribing information on October 31, 2026, Divigel was on it, and Divigel's DailyMed label shows the heart, breast cancer and dementia statements removed from its boxed warning in February 2026. EstroGel was not on the list, and its DailyMed label still showed the older boxed warning.

What that means for you

The FDA has asked for these changes, but EstroGel's label hadn't been updated when we checked. Even after an update, the endometrial cancer warning is expected to stay for estrogen-only products like EstroGel, and the contraindications below still apply. Our menopause hormone therapy safety update explains the changes in more detail.

The patient information also says to have a pelvic exam, breast exam and mammogram every year unless your clinician tells you otherwise, and to talk with your clinician regularly, for example every 3 to 6 months, about whether you still need treatment.

Who shouldn't use EstroGel

The label says not to use EstroGel if you have:

• unusual vaginal bleeding that hasn't been checked by a clinician
• breast cancer now or in the past
• an estrogen-dependent cancer
• a blood clot in your legs or lungs now or in the past
• a stroke or heart attack now or in the past
• liver problems or liver disease
• a known blood clotting disorder, such as protein C, protein S or antithrombin deficiency
• a past allergic reaction or angioedema with EstroGel

The label also says estrogen can make some conditions worse, including asthma, diabetes, epilepsy, migraine, lupus, porphyria and liver blood vessel growths (hepatic hemangiomas). Women taking thyroid medicine may need their thyroid levels checked. If you're having surgery or will be on bed rest, the label says to stop estrogen 4 to 6 weeks beforehand when possible. Some medicines and supplements, including St. John's wort, can change how estrogen is broken down, so tell your clinician everything you take.

Our guide to who shouldn't take HRT and HRT and blood clots go further.

Cost, coverage and generics

None of the EstroGel reviews we found talked about price, though cost and insurance come up often in reviews of other estradiol gels. Prices and coverage change, so we keep them on a separate page that we check and date: EstroGel cost without insurance.

On generics: when we checked DailyMed on October 31, 2026, it listed a generic estradiol gel 0.06% pump from Encube Ethicals with the same 1.25 g dose per pump, containing 0.75 mg of estradiol. Ask your pharmacist whether a generic can be substituted for your prescription. If you're comparing gels more broadly, see estradiol gel online and Elestrin alternatives.

How EstroGel compares with other estradiol options

Review data for estradiol gels is thin across the board, but here's what we found on October 31, 2026, alongside what each label says.

A few honest notes on this table. The Drugs.com Divigel and Elestrin numbers are small samples, and four reviews for Elestrin say very little. Gel users often mention the drying time and keeping others from touching the area. Patch users more often mention adhesive and skin irritation. Neither is better for everyone.

For direct comparisons, see EstroGel vs Divigel, estradiol patch vs gel, estradiol gel vs spray and estradiol pill reviews.

Who tends to do well on EstroGel, and who struggles

Based on the label and the patterns in reviews, here's who EstroGel may suit and who may want to talk through other options. This isn't a substitute for a clinician's judgment.

It may suit you if:

• your main problem is hot flashes or night sweats, and you've talked through the benefits and risks with a clinician
• you'd rather not take a pill, or a clinician prefers a through-the-skin option for you
• patches irritate your skin or won't stay on
• you can build a daily routine: apply after showering, let it dry, then dress

You may struggle, or need a different plan, if:

• you have a uterus and haven't talked about progestogen protection
• you often have skin contact with children, a partner or pets in the hour after you'd apply it
• you're prone to headaches or migraines, since headache was one of the more common side effects
• vaginal dryness is your only symptom, in which case vaginal estrogen is usually tried first
• you have any of the conditions in the contraindications list above

Questions to ask your clinician about EstroGel

• Is a systemic estrogen right for my symptoms, or would a vaginal product do?
• Do I need a progestogen, and which one?
• Is one pump the right dose for me? What should I do if it isn't enough?
• How will we know if it's working, and when should I check back?
• Which side effects should I watch for, and which ones need a call?
• Can I use moisturizer or sunscreen on that arm?
• Is a generic estradiol gel 0.06% an option?
• Should I switch to a patch or another gel if I have skin problems?
• How do the FDA's 2025–2026 label changes apply to me?

Write your answers down. The patient information suggests reviewing your treatment with your clinician every 3 to 6 months.

Can you get EstroGel through online menopause care?

Some online menopause services prescribe estradiol gel, though which products they offer varies. Our EstroGel online guide covers what to expect. Here's how our five pillars apply:

• Clinical legitimacy: a licensed clinician should take a full history before prescribing, including any abnormal bleeding and any history of breast cancer, clots, stroke, heart disease or liver disease.
• Care quality: look for clear follow-up, a plan for side effects and unexpected bleeding, and a route to in-person care when you need an exam.
• Medication fit: a good service can discuss more than one estrogen option, such as gel, patch, spray or pill, plus progestogen protection if you have a uterus and nonhormonal choices if estrogen isn't right for you.
• Price transparency: you should know what visits, refills and the medicine itself are likely to cost before you start.
• Access: you'll still need regular breast and pelvic exams and mammograms, and some symptoms, like bleeding or a new breast lump, need an in-person exam.

See is online HRT safe? for how to judge a service.

Frequently asked questions

Are EstroGel reviews mostly good or bad?

Mostly good, but there are very few. On October 31, 2026, Drugs.com had no EstroGel reviews, and we found 12 that named it among 772 WebMD reviews on a page that pools many estradiol skin products. Of the 11 describing their own EstroGel use, 8 rated it 4 or 5 out of 5, and 2 stopped because of side effects.

How long does EstroGel take to work?

In the label's trial, hot flashes were significantly lower than with placebo by week 4, and they kept falling through week 12. Reviewers described changes from about two weeks to a month or more. If you're not seeing improvement, talk to your clinician rather than adding pumps on your own.

What are the most common side effects of EstroGel?

In trials, breast pain (10.7%), headache (9.5%) and gas (5.4%) were the most common. The patient information also lists stomach cramps, bloating, nausea and vomiting, hair loss, fluid retention and vaginal yeast infections. Reviewers most often described breast tenderness, headaches, nausea and stomach upset.

Can EstroGel cause hair loss or weight gain?

The label's list of reports since approval includes hair loss and weight gain, and one EstroGel reviewer reported hair loss. Because these reports are voluntary, the label says it isn't always possible to tell how often they happen or whether the gel caused them. Our guide to whether HRT causes weight gain covers what the research shows.

Where do you apply EstroGel?

The U.S. label says to spread one pump thinly over one arm, inside and outside, from wrist to shoulder, on clean, dry skin. Don't massage it in, and don't put it on your breasts or vagina. Some reviewers applied it to their thighs, which isn't what the U.S. label says.

Can my partner or kids be exposed to EstroGel?

Yes, it can transfer to others. The label says to avoid skin contact on the application area for at least 1 hour. MedlinePlus recommends covering the area with clothing and warns that topical estradiol can harm others, especially men, children and pets. Wash your hands after applying.

Does EstroGel still have a black box warning?

Yes, when we checked on October 31, 2026. The FDA asked in November 2025 for changes to menopause hormone therapy boxed warnings and approved the first updated labels in February 2026, but EstroGel wasn't on the FDA's updated-label list. For estrogen-only products, the endometrial cancer warning is expected to stay.

Can Find My HRT Path tell me if EstroGel is right for me?

No. Find My HRT Path asks about your symptoms, what you've tried, your age, your state and your health history, and points you to a featured care option or flags when online care isn't the right start. Only a clinician who knows your history can decide on a prescription.

The bottom line

EstroGel has far fewer public reviews than its long history might suggest. The handful we found were mostly positive, especially about sleep and hot flashes, with breast tenderness, headaches and stomach upset as the main complaints. The label's trial shows real but not complete hot flash relief over 12 weeks. The boxed warning still applies, you'll need progestogen protection if you have a uterus, and the daily routine of applying it and keeping others away from it matters.

If you're weighing EstroGel against other ways to treat hot flashes and night sweats, Find My HRT Path can help you see what fits and flag when in-person care should come first.

Related reading

• EstroGel online
• EstroGel vs Divigel
• EstroGel cost without insurance
• How to apply estradiol gel
• Estradiol patch vs estradiol gel
• Divigel online
• Estradiol patch reviews
• CombiPatch reviews

Sources

All sources were read on October 31, 2026.

1. EstroGel (estradiol gel) 0.06% prescribing information and patient information, ASCEND Therapeutics US, LLC. DailyMed, US National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=762ac371-bb8b-47e7-b48f-e80d452c9dd4
2. EstroGel. Drugs.com. https://www.drugs.com/compare/estrogel
3. Estradiol transdermal (Climara, Divigel, Dotti, Elestrin, EstroGel, Evamist, Lyllana, Menostar, Minivelle, Vivelle-Dot) user reviews. WebMD. https://reviews.webmd.com/drugs/drugreview-89430-estrogel-transdermal
4. Divigel user reviews and ratings. Drugs.com. https://www.drugs.com/comments/estradiol/divigel.html
5. Elestrin user reviews and ratings. Drugs.com. https://www.drugs.com/comments/estradiol/elestrin.html
6. Divigel (estradiol gel) 0.1% prescribing information, Vertical Pharmaceuticals, LLC. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=59e610dc-883e-4f07-9ec6-a5841b0bf9fb
7. Elestrin (estradiol gel) 0.06% prescribing information, Viatris Specialty LLC. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=eff2dea1-f117-11e3-ac10-0800200c9a66
8. Estradiol gel 0.06% prescribing information, Encube Ethicals, Inc. DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=54f108d6-ddd2-4276-8508-2c8e16a65fb2
9. The 2022 hormone therapy position statement of The North American Menopause Society. Menopause, 2022;29(7):767–794. https://pubmed.ncbi.nlm.nih.gov/35797481/
10. Estradiol Topical. MedlinePlus Drug Information, US National Library of Medicine. https://medlineplus.gov/druginfo/meds/a605041.html
11. US Food and Drug Administration. FDA requests labeling changes related to safety information to clarify benefit/risk considerations of menopausal hormone therapy (November 10, 2025). https://www.fda.gov/drugs/drug-alerts-and-statements/fda-requests-labeling-changes-related-safety-information-clarify-benefitrisk-considerations
12. US Food and Drug Administration. FDA approves labeling changes for menopausal hormone therapy products (February 12, 2026). https://www.fda.gov/news-events/press-announcements/fda-approves-labeling-changes-menopausal-hormone-therapy-products
13. US Food and Drug Administration. Menopausal hormone therapies with updated prescribing information. https://www.fda.gov/drugs/drug-safety-and-availability/menopausal-hormone-therapies-updated-prescribing-information
14. US Food and Drug Administration. MedWatch: the FDA safety information and adverse event reporting program. https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program

This page is for education only and is not medical advice. It doesn't replace an examination, diagnosis or treatment plan from a clinician who knows your health history. If you have unusual vaginal bleeding, a new breast lump, changes in vision or speech, a sudden severe headache, severe pain in your chest or legs, or swelling of your face, lips or tongue while using EstroGel, contact a clinician promptly or call 911 in an emergency. You can report side effects to the FDA through MedWatch at 1-800-FDA-1088.