Menest Cost Without Insurance: What Menest Tablets Cost, and Why They're Getting Hard to Find

By The HRT Index Editorial Team · Editorial research — not medically reviewed · Last updated November 3, 2026 · Last verified November 3, 2026

Menest cost without insurance was about $43 to $80 for 30 tablets in the price tools we checked on November 3, 2026, and $193 to $374 for a 100-tablet bottle. But Pfizer has discontinued Menest, and no generic esterified estrogens tablet is sold. Finding it may be harder than paying for it.

The HRT Index is the independent decision resource for online menopause and HRT care — comparing telehealth providers on clinical legitimacy, care quality, medication fit, price transparency, and access, with every claim verified and dated, so women can choose the path that fits their situation before their first consult.

What we actually verified · Last verified November 2026

• What we read on November 3, 2026: the Drugs.com price guide for Menest; the WebMDRx coupon page for Menest; Pfizer's Menest label and listing on DailyMed; the Menest application records in FDA's Drugs@FDA database; FDA's National Drug Code (NDC) Directory files and their definitions; FDA's drug shortage database; and the ASHP drug shortage lists. We also read The Menopause Society's 2022 hormone therapy position statement. Every source is listed at the bottom.
• What we could not read: GoodRx and SingleCare blocked our automated checks, so we show no GoodRx or SingleCare prices.
• What we did not do: we did not fill a prescription, call a pharmacy to check stock, ask Pfizer about Menest, or check any insurer's formulary. The price at the counter is the only one that counts.
• Commercial interest: The HRT Index may earn a commission from some providers featured through The HRT Index's Find My HRT Path tool. No drug maker, pharmacy or discount card company paid for or reviewed this page, and this page links to no provider. See our affiliate disclosure.
• Verification Standard: we judge menopause care options on five pillars, in this order: clinical legitimacy, care quality, medication fit, price transparency and access. Our methodology explains how.

Jump to: Prices · Monthly and yearly cost · Is Menest discontinued? · Is there a generic? · What Menest is · Safety · Insurance and savings · If you can't get Menest · Questions for your clinician · FAQ · Sources

Menest cost by strength and quantity: the dated prices

Price tools still list Menest in four strengths: 0.3 mg, 0.625 mg, 1.25 mg and 2.5 mg. On November 3, 2026, the lowest prices we found were $43.13 for 30 tablets of 0.625 mg on Drugs.com and $79.59 for 30 tablets of 0.3 mg with a free WebMDRx coupon at CVS.

A listed price is not proof a pharmacy has Menest on the shelf. Read the availability section before you count on these numbers.

Cash and coupon prices read November 3, 2026. Prices vary by pharmacy, location and day.

How to read the table:

• A coupon cut the shelf price by about 43% in our check. WebMDRx showed CVS's original price for 30 tablets of Menest 0.3 mg as $140.36 and its coupon price as $79.59.
• A bigger bottle was not always cheaper. On Drugs.com, 30 tablets of 0.625 mg worked out to $1.44 a tablet, while the 100-tablet bottle worked out to $2.70. Ask your pharmacy to price both.
• Higher strengths cost more per tablet. Drugs.com's per-tablet price rose from $1.93 for 0.3 mg to $3.74 for 1.25 mg and $5.36 for 2.5 mg.
• Location matters. WebMDRx prices were for its default ZIP code (33186), and Drugs.com does not say which location its prices are for. Expect different numbers near you.
• No manufacturer help. Drugs.com said it found no manufacturer promotions and no patient assistance programs for Menest on November 3, 2026.

For comparison, other oral estrogens on our site cost less. In our estradiol cost without insurance check on October 27, 2026, 30 generic estradiol tablets cost $10.24 to $12.57 with a GoodRx coupon in Denver. In our generic Premarin cost snapshot from June 8, 2026, 30 generic conjugated estrogens 0.625 mg tablets cost $61.58 with a GoodRx coupon. These are different medicines, so a lower price alone isn't a reason to switch. It is a good question to bring to your clinician.

What Menest costs per month and per year

What you pay each month depends on your strength and schedule. At the prices above, one four-week cycle on the label's schedule came to roughly $30 to $79, depending on strength and where you buy.

The Menest label lists a usual dose of 1.25 mg a day for hot flashes and night sweats (called vasomotor symptoms), given in cycles such as three weeks on and one week off, and it describes this use as short-term. For vaginal dryness and related symptoms, it lists 0.3 mg to 1.25 mg or more a day, also in cycles. It says to start at the lowest dose. Your prescriber decides your actual dose and schedule. The rows below are examples for budgeting, not dosing advice.

Our arithmetic on November 3, 2026 prices. Not quotes.

A year at the label's usual 1.25 mg dose, 3 weeks on and 1 week off (13 four-week cycles, 273 tablets): about $1,021 at $3.74 a tablet. At 0.625 mg on the same schedule, about $392 at $1.44 a tablet or $738 at $2.70. These totals are per-tablet math. You'd actually buy whole bottles, and prices will change during the year.

The tablets are only part of the cost. You also need a prescriber, and the label says women on estrogen should be rechecked periodically, for example every 3 to 6 months. If you have a uterus, you'll usually also need a progestogen (a progesterone-type medicine) with your estrogen, which adds its own cost. Ask what visits, labs and any second prescription will cost before you budget.

The right online menopause care isn't the same for every woman — it depends on your symptoms, what you've already tried, your age, your state and your health history. Some situations belong with an in-person clinician first. Use The HRT Index's Find My HRT Path tool to explore a featured care option for your situation — and to flag when online care isn't the right starting point — before your first consult. It's free, asks 5 quick questions, takes about 60 seconds and needs no email. It is not a diagnosis or a treatment plan.

Is Menest discontinued?

Yes, as far as FDA's public records show. Drugs@FDA lists all four Menest strengths as "Discontinued," and FDA's National Drug Code (NDC) Directory lists all four Pfizer Menest product codes as discontinued by the firm. We found no public announcement from Pfizer, and we did not contact Pfizer.

Here is what each record says, read November 3, 2026:

What the end dates mean. FDA describes the marketing end date as the date a product will no longer be available. When a product is no longer made, FDA says that in most cases it recommends companies use the expiration date of the last lot produced. Both Menest end dates have now passed.

Why it isn't on the shortage lists. Shortage lists track medicines that are in short supply. A product its maker has stopped selling is a discontinuation, not a shortage, so its absence from those lists is not good news about supply.

What it means for you:

• Price tools can lag. Drugs.com and WebMDRx still showed Menest prices on November 3, 2026. That's price data, not a stock check. Call your pharmacy before you rely on a refill.
• Check the expiration date on any Menest you are dispensed.
• Plan now, not at your last tablet. If you take Menest, ask your prescriber what you'll switch to so you don't have a gap in treatment.

If your refill is already a problem, Find My HRT Path can help you look at care options for your situation, or tell you when an in-person clinician is the better start.

Is there a generic Menest?

No generic Menest is sold now. Drugs@FDA lists every esterified estrogens tablet it has on record, brand or generic, as discontinued. That includes Estratab, Evex, Femogen, Amnestrogen and generic esterified estrogens from other makers. A search of FDA's current NDC Directory on November 3, 2026 found no active product with esterified estrogens as its only active ingredient.

Two things often get mixed up with Menest:

• Esterified estrogens and methyltestosterone (EEMT, Covaryx, Estratest). These tablets contain esterified estrogens plus a testosterone-type medicine. They are a different product, not a Menest generic, and none of them is FDA-approved. FDA has set May 4, 2027 as the date shipping them across state lines without an approved application becomes unlawful. Our Covaryx cost page explains.
• Conjugated estrogens (Premarin and its generics). The names sound alike, but conjugated estrogens and esterified estrogens are different drug mixtures. Our Premarin alternatives guide covers the difference.

Ask your pharmacist before treating any of these as a substitute for Menest.

What Menest is and what it's used for

Menest is a prescription tablet of esterified estrogens, a mix of estrogen compounds, taken by mouth. It is an FDA-approved product: Drugs@FDA lists the Menest applications as approved in 1977, and Pfizer's label on DailyMed was last revised in February 2024.

What the label says it treats:

1. Moderate to severe hot flashes and night sweats from menopause.
2. Moderate to severe vaginal and vulvar symptoms from menopause, such as dryness. The label says vaginal products should be considered when these are the only symptoms.
3. Low estrogen from female hypogonadism, removal of the ovaries (female castration) or primary ovarian failure.
4. Some advanced breast and prostate cancers, for symptom relief only.

What the tablets look like (from the label):

• 0.3 mg: yellow oblong tablet marked "M72," bottles of 100.
• 0.625 mg: orange oblong tablet marked "M73," bottles of 100.
• 1.25 mg: green oblong tablet marked "M74," bottles of 100.
• 2.5 mg: pink oblong tablet marked "M75," bottles of 50.

Menest safety: the boxed warning and who shouldn't take it

Menest carries the same kind of boxed warning as other estrogens. Your price check should never decide whether it's safe for you, so here is what the label says.

Boxed warning, in plain words:

• Endometrial cancer. Estrogen alone raises the risk of cancer of the uterine lining. If you have a uterus, the label says a progestin should be added. Unusual vaginal bleeding needs to be checked.
• Heart disease, stroke, blood clots and breast cancer. The label says estrogens should not be used to prevent heart disease. It cites the Women's Health Initiative study, which found higher risks of heart attack, stroke, invasive breast cancer and blood clots in women aged 50 to 79 taking a different oral estrogen plus a progestin.
• Dementia. A part of that study found a higher risk of probable dementia in women 65 and older.
• Lowest dose, shortest time. The label says estrogen should be used at the lowest effective dose for the shortest time that meets your treatment goals.

The label says not to take Menest if you have: unexplained genital bleeding; breast cancer now or in the past (except selected patients being treated for metastatic disease); an estrogen-dependent cancer; a blood clot in a leg or lung now or in the past; a stroke or heart attack in the past year; liver disease; an allergy to its ingredients; or a known or suspected pregnancy.

The bigger picture. The Menopause Society's 2022 position statement says that for women younger than 60, or within 10 years of menopause onset, with no reasons to avoid it, the benefit-risk ratio of hormone therapy is favorable for bothersome hot flashes and preventing bone loss. Your own risks decide the answer for you. That's a conversation for your clinician.

Does insurance cover Menest, and how can you save?

Coverage depends on your plan, and a discontinued drug may drop off formularies. Ask your plan whether Menest, or the medicine you'd switch to, is covered. We did not check any insurer's coverage.

Ways to lower the cost while Menest is still in your hands:

1. Compare coupon prices. A free pharmacy discount card cut the price about 43% in our WebMDRx check. Our HRT prescription discount card guide explains how these cards work.
2. Ask about quantity. In our check, 30 tablets of 0.625 mg cost less per tablet than 100. Your pharmacy's math may differ.
3. Don't count on a savings card. Drugs.com found no Menest manufacturer coupon, copay card or patient assistance program.
4. Price the switch, too. If you'll have to change medicines anyway, ask what the new one costs with your insurance and without it.

What to ask about if you can't get Menest

If your pharmacy can't fill Menest, your prescriber can choose another estrogen. These are some FDA-approved options people ask about. Only your clinician can say which fits you and at what dose, so don't assume milligrams carry over from one estrogen to another.

If you have a uterus, ask about the progestogen that goes with your new estrogen. ASHP's current list also includes a progesterone capsule shortage, so ask about supply for that, too. Our FDA-approved HRT medication list shows the wider set of approved options.

Not sure where to start? Find My HRT Path asks about your symptoms, what you've tried, your age, your state and your health history. Then it shows a featured care option, or tells you when online care isn't the right place to start.

Questions to ask before your next Menest refill

Take these to your prescriber or pharmacist. They turn a price question into a plan.

1. Can you still get Menest for me, and how many refills' worth can you find?
2. What will I switch to when it runs out, and at what dose?
3. What does the new medicine cost with my insurance and without it?
4. Do I need a progestogen with my estrogen if I have a uterus? Is that medicine in stock?
5. Should the new estrogen be a pill, a patch or a gel for my health history?
6. When should I be rechecked after a switch, and what will that visit cost?

Who should see an in-person clinician first?

Price should never decide whether a hormone is safe for you. See a clinician in person before starting, changing or stopping Menest if you have unexplained vaginal bleeding, a history of breast or uterine cancer, blood clots, stroke, heart attack or liver disease, or if you might be pregnant. Find My HRT Path flags situations like these and points you to guidance instead of an online visit when that's the safer start.

Find the route that fits you

If Menest is getting hard to find or afford, start with your situation. Find My HRT Path is free and takes about 60 seconds. It shows a featured care option, or tells you when online care isn't the right place to start.

Frequently asked questions about Menest cost

How much does Menest cost without insurance?

On November 3, 2026, Drugs.com listed 30 Menest 0.625 mg tablets for $43.13, and WebMDRx showed 30 tablets of 0.3 mg for $79.59 with its free coupon at CVS. Prices vary by pharmacy and location, and a listed price doesn't mean a pharmacy has Menest in stock.

What does Menest cost per month?

On the label's usual schedule of one tablet a day for three weeks out of four, about $30 to $79 per four-week cycle at the per-tablet prices we found, depending on strength. Your prescriber sets your actual dose and schedule.

Is Menest discontinued?

FDA's records say yes. Drugs@FDA lists all four strengths as discontinued, and FDA's NDC Directory marks all four Pfizer Menest product codes as discontinued by the firm. The listing's marketing end dates were February 28 and April 30, 2026.

Is there a generic for Menest?

No generic esterified estrogens tablet is sold now. Drugs@FDA lists every esterified estrogens tablet on record as discontinued.

Is Menest the same as Premarin?

No. Menest contains esterified estrogens, and Premarin contains conjugated estrogens. They are different drug mixtures, so ask your clinician before switching.

Is Menest the same as EEMT or Covaryx?

No. EEMT and Covaryx add methyltestosterone to esterified estrogens, and none of those combination tablets is FDA-approved. Menest contains esterified estrogens only.

Is there a Menest coupon or savings card?

Drugs.com found no manufacturer promotions or patient assistance programs for Menest on November 3, 2026. A free pharmacy discount card showed a coupon price about 43% below the regular price in our check.

Is Menest on the FDA drug shortage list?

No. On November 3, 2026, neither FDA's drug shortage database nor ASHP's lists had an entry for Menest or esterified estrogens. A discontinued product isn't the same as one in shortage.

What strengths does Menest come in?

The label lists 0.3 mg, 0.625 mg and 1.25 mg tablets in bottles of 100, and 2.5 mg tablets in bottles of 50.

Does insurance cover Menest?

It depends on your plan, and a discontinued drug may no longer be on the formulary. Ask your plan directly. We did not check any insurer's coverage.

How we checked this page, and its limits

This is editorial research and is not medical advice. It is not medically reviewed (medical review policy). A clinician who knows your history should decide what you take. If we get something wrong, tell us.

Limits:

• WebMDRx's coupon price is for its default location, ZIP 33186, read November 3, 2026. Drugs.com cash prices were read the same day; Drugs.com does not name a location. GoodRx and SingleCare blocked our automated checks, so their prices are not included.
• Monthly and yearly figures are our arithmetic on one day's prices, using example schedules. They are not quotes or dosing advice.
• We did not check pharmacy stock, any insurer's formulary, or ask Pfizer about its plans for Menest.
• Estradiol and generic Premarin prices come from our own earlier checks on the dates shown.

Sources (all read November 3, 2026):

• U.S. National Library of Medicine, DailyMed. Menest (esterified estrogens tablets, USP), Pfizer label and listing.
• U.S. Food and Drug Administration, Drugs@FDA. Menest 0.625 mg, ANDA 084948; Menest 2.5 mg, ANDA 084949; Menest 1.25 mg, ANDA 084950; Menest 0.3 mg, ANDA 084951.
• U.S. Food and Drug Administration. National Drug Code Directory, including its excluded drugs file, and NDC product file definitions.
• U.S. Food and Drug Administration. Drug shortage database.
• American Society of Health-System Pharmacists. Drug shortages list.
• The Menopause Society. The 2022 hormone therapy position statement of The North American Menopause Society.
• Drugs.com. Menest price guide.
• WebMDRx. Menest coupon page.

Questions about our process: methodology, editorial standards and affiliate disclosure.