HRT Injections for Menopause: What's Available, How They Compare and Who They Fit

By The HRT Index Editorial Team · Editorial research — not medically reviewed · Last updated November 2, 2026 · Last verified November 2, 2026

HRT injections for menopause are a real, FDA-approved option: estradiol valerate (Delestrogen and generics) and estradiol cypionate (Depo-Estradiol) are labeled for moderate to severe hot flashes. But they're usually given in a clinic every 3 to 4 weeks, levels rise and fall between shots, and the routes major guidelines list are pills, patches, gels, sprays and rings.

The HRT Index is the independent decision resource for online menopause and HRT care — comparing telehealth providers on clinical legitimacy, care quality, medication fit, price transparency, and access, with every claim verified and dated, so women can choose the path that fits their situation before their first consult.

What we actually verified · Last verified November 2026

• What we read: the current FDA prescribing information on DailyMed for Delestrogen (estradiol valerate injection, label dated May 2026), Depo-Estradiol (estradiol cypionate injection, label dated February 2024) and Depo-Testosterone (testosterone cypionate injection, label dated August 2026); the MedlinePlus patient monograph on estrogen injection; The Menopause Society's 2022 hormone therapy position statement; ACOG's patient FAQ on hormone therapy for menopause and the abstract of its 2023 Clinical Consensus on compounded bioidentical hormones; the Femring label; the 2019 Global Consensus Position Statement on testosterone therapy for women; a March 2025 VA clinical summary on testosterone for women; the FDA's February 2026 announcement on hormone therapy label changes; and a 1980 study comparing how estradiol injections are absorbed. Every source is listed at the bottom with the date we read it.
• What we did not do: we did not examine anyone, check anyone's hormone levels, give or receive an injection, or speak with a clinician for this page. We did not verify current cash prices for estrogen injections, so we don't quote any. This is editorial research, not medical review, and not advice for your situation.
• Commercial interest: The HRT Index may earn a commission from some providers featured through The HRT Index's Find My HRT Path tool. No provider paid for this page, and no provider reviewed it. See our affiliate disclosure.
• Verification Standard: we judge online menopause care on five pillars, in this order: clinical legitimacy, care quality, medication fit, price transparency and access. Our methodology explains how.

Jump to: Quick answer · Which injections exist · How shots work · Shots vs patches, gels and pills · Why guidelines don't start here · If you have a uterus · Safety and who shouldn't · Testosterone injections · Injections vs pellets · Who might ask about shots · Cost and insurance · How to get them · Questions to ask · Online care · FAQ · Sources

HRT injections for menopause: the quick answer for your situation

Estrogen injections can treat menopause hot flashes, but they're a less common route with real tradeoffs. Testosterone injections are a different story: no testosterone product is FDA-approved for women in the US, and expert guidance advises against injections. This table sums up what the sources below say. It's a starting point for a talk with your clinician, not a decision.

Bottom line for most women: estrogen injections are an approved but niche choice. They usually make the most sense to discuss when other routes have failed or don't suit you, and only with a clinician who will manage the progestogen, the timing of shots and your follow-up.

The right online menopause care isn't the same for every woman — it depends on your symptoms, what you've already tried, your age, your state and your health history. Some situations belong with an in-person clinician first. Use The HRT Index's Find My HRT Path tool to explore a featured care option for your situation — and to flag when online care isn't the right starting point — before your first consult.

Find My HRT Path is free, takes about 60 seconds and doesn't ask for your email. It asks five quick questions about your symptoms, what you've already tried, your age, your state and your health history. It isn't an eligibility test, a diagnosis or a prescription decision, and it won't choose a route like injections for you.

Which HRT injections are available in the US?

Two estrogen injections are FDA-approved for menopause hot flashes in the US: estradiol valerate and estradiol cypionate. Both are estradiol attached to a chemical "tail" (an ester) and dissolved in oil, so the body absorbs them slowly from the muscle. A third injectable estrogen and the common testosterone shots exist too, but they aren't approved for menopause symptoms in women.

A few label details worth knowing:

• The oils differ. Delestrogen's 10 mg/mL strength is made in sesame oil. Its 20 and 40 mg/mL strengths are made in castor oil with benzyl benzoate and benzyl alcohol. Depo-Estradiol is made in cottonseed oil. Both labels say not to use the product if you're allergic to any of its ingredients, so tell your clinician about allergies to sesame, castor oil or cottonseed.
• Both contain a preservative called chlorobutanol (Delestrogen's 10 mg/mL strength and Depo-Estradiol). The Depo-Estradiol label notes that "chlorobutanol may be habit forming."
• Who gives the shot. MedlinePlus says these injections "are usually injected by a health care professional once every 3 to 4 weeks."
• For vaginal symptoms only, a vaginal product comes first. The Delestrogen label says that when the goal is only vulvar and vaginal atrophy, "topical vaginal products should be considered." See vaginal estrogen vs systemic estrogen.

Those doses come straight from the FDA labels and are here so you can recognize what you're offered. They're not a recommendation for you. Your clinician chooses the dose and schedule, and the labels say to use "the lowest dose and regimen that will control symptoms."

How estrogen shots work: peaks, dips and a dose you can't take back

An estradiol injection releases estrogen into your blood over days to weeks. Levels climb to a peak within a few days, then drift down until the next shot. That rise-and-fall pattern, and the fact that a dose can't be removed once it's given, are the biggest practical differences from a patch, gel or pill.

The FDA labels explain the slow release: because the estradiol is in oil, "a single intramuscular injection of estradiol valerate or estradiol cypionate is absorbed over several weeks."

The best-known head-to-head absorption study is old and small, but it shows the shape clearly. In 1980, Oriowo and colleagues gave a single 5 mg injection of estradiol valerate, cypionate or benzoate to groups of 9 or 10 women and measured their blood levels every day for three weeks.

Keep the limits in mind. The women in that study were taking birth control pills to suppress their own hormones, they weren't in menopause, and the dose isn't the one used for menopause symptoms. The numbers won't match what happens with your dose. The point is the pattern: injections give a peak, then a decline.

What that can mean in daily life:

• Relief can come quickly. MedlinePlus says that when estrogen injection is used for hot flashes, "your symptoms should improve within 1 to 5 days after you receive the injection."
• Symptoms can creep back before the next shot. As levels fall, some women may notice hot flashes returning toward the end of the cycle. That's a reason to keep a symptom diary and share it with your clinician.
• Side effects are harder to undo. With a patch or gel, you can take it off or stop using it. With a shot, the estrogen is already in the muscle and keeps releasing.
• Visits are built in. If a clinic gives your shots, you'll have a visit every few weeks. Some women find that reassuring. Others find it hard to fit in.

HRT injections vs patches, gels, sprays, rings and pills

Patches, gels, sprays and systemic vaginal rings are designed to deliver estradiol through the skin or vaginal wall day by day, and pills are taken daily. Injections are the least frequent option, but levels swing the most between doses. The table below compares the routes using the FDA labels, The Menopause Society's 2022 statement and ACOG's patient guidance.

The 2022 statement says it plainly: for hot flashes, "systemic estrogens can be prescribed as oral drugs; transdermal patches, sprays, and gels; or as vaginal rings." ACOG's patient FAQ gives the same examples of systemic estrogen: "pills, skin patches, gels, and sprays." Neither lists injections.

If steady levels, easy stopping and a lower-clot-risk route matter to you, a patch, gel or spray usually covers those goals. If you can't use skin products and want to avoid daily pills, a systemic vaginal ring or an injection is a reasonable thing to ask about.

Read more in oral vs transdermal estrogen, estradiol patch vs pill, once-weekly vs twice-weekly estradiol patch, estradiol gel online, estradiol spray online, Femring reviews and types of HRT.

Why guidelines don't usually start with injections

The guidance we read doesn't rule out estrogen injections, and the FDA approved them for hot flashes. It just doesn't list them among the usual systemic routes. Our reading of the sources is that other routes are easier to fine-tune or stop and have more research behind them.

Three themes in the sources point that way:

• Lowest effective dose and regular review. The Menopause Society says "the appropriate, often lowest, effective dose of systemic ET [estrogen therapy] consistent with treatment goals" should be the goal. The injection labels ask clinicians to try tapering or stopping "at 3-month to 6-month intervals." Fine-tuning is simpler with a daily gel or a patch strength than with a shot that lasts weeks.
• More evidence for other routes. The Women's Health Initiative, the large trial behind the boxed warnings, used pills. The route research The Menopause Society cites on clot risk compares pills with transdermal therapy, not injections. The injection labels say that for forms not studied in the WHI, the risks "should be assumed to be similar."
• Timing still matters most. The Menopause Society's position statement says that for women "aged younger than 60 years or who are within 10 years of menopause onset and have no contraindications, the benefit-risk ratio is favorable for treatment of bothersome VMS [hot flashes and night sweats] and prevention of bone loss." For women who start later, it says the balance "appears less favorable." That applies to every route, including injections.

If you have a uterus, an estrogen shot still needs a progestogen

Yes. The Delestrogen label says that "when estrogen is prescribed for a postmenopausal woman with a uterus, progestin should also be initiated to reduce the risk of endometrial cancer," and the Depo-Estradiol label says the same. Both labels add that "a woman without a uterus does not need progestin."

The boxed warning at the top of both labels starts with "estrogens increase the risk of endometrial cancer," meaning cancer of the uterine lining. MedlinePlus adds that the progestin "may decrease your risk of developing endometrial cancer, but may increase your risk of developing certain other health problems, including breast cancer."

In practice, the shot covers only the estrogen part of your HRT. The progestogen is usually a separate pill, such as micronized progesterone, or another form your clinician chooses. Unexpected or persistent vaginal bleeding while on estrogen should be checked; the labels call for "adequate diagnostic measures, including endometrial sampling when indicated."

See do you need progesterone if you have a uterus?, estrogen-only vs estrogen plus progesterone, progestin vs progesterone and HRT after hysterectomy.

Safety: boxed warnings and who shouldn't use estrogen injections

The current Delestrogen and Depo-Estradiol labels on DailyMed carry a boxed warning about endometrial cancer, plus the older boxed language on heart attack, stroke, breast cancer, blood clots and dementia from the Women's Health Initiative. The labels also list specific situations where estrogen shouldn't be used.

Labels are changing. In February 2026, the FDA announced it had approved label changes for six menopausal hormone therapy products that removed the cardiovascular disease, breast cancer and probable dementia statements from the boxed warning. The FDA said it started this process in November 2025 and that 29 companies had submitted proposed changes. When we checked on November 2, 2026, the two estrogen injection labels on DailyMed still showed the older boxed warning. That wording may change, but these risks are still described in other parts of hormone therapy labels, so they're worth discussing with your clinician. Our FDA HRT label change tracker follows which products have changed.

What the injection labels' boxed warning says today

• Endometrial cancer: "Estrogens increase the risk of endometrial cancer."
• Heart and other risks: estrogens with or without progestins "should not be used for the prevention of cardiovascular disease." The WHI "reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis" in women aged 50 to 79 taking oral conjugated estrogens plus medroxyprogesterone acetate.
• Dementia: the WHI Memory Study found a higher risk of probable dementia in women 65 and older on that combination. The labels say "it is unknown whether this finding applies to younger postmenopausal women."
• Lowest dose, shortest time: the labels say estrogens should be prescribed "at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman." The Menopause Society's 2022 statement adds that longer use can be appropriate for documented reasons such as persistent hot flashes, with shared decision-making and regular review.

Who shouldn't use estrogen injections

Both the Delestrogen and Depo-Estradiol labels list these contraindications:

• Undiagnosed abnormal genital bleeding
• Known or suspected breast cancer (the Delestrogen label adds "history of" breast cancer)
• Known or suspected estrogen-dependent cancer
• Active deep vein thrombosis or pulmonary embolism, or a history of either
• Active or recent (for example, within the past year) arterial clotting disease, such as stroke or heart attack
• Liver dysfunction or disease
• Known allergy to any ingredient
• Known or suspected pregnancy

Warning signs that need prompt care

MedlinePlus lists symptoms to report to your doctor "immediately" while using estrogen injection, including a sudden severe headache, sudden severe vomiting, speech problems, dizziness or faintness, sudden vision loss or double vision, weakness or numbness of an arm or leg, crushing chest pain, coughing up blood, sudden shortness of breath, breast lumps, and pain, tenderness or redness in one leg. Call 911 for signs of a stroke, heart attack or a clot in the lungs.

See who should not take HRT, HRT contraindications and HRT side effects.

Testosterone injections for women in menopause

No testosterone product is FDA-approved for women in the US. Testosterone shots such as testosterone cypionate are approved for men, and international expert guidance specifically advises against injections for women because they can push levels well above the normal female range.

What the sources say:

• Approval: a March 2025 VA clinical summary states: "There are no FDA approved testosterone products indicated for use in women in the U.S." The Depo-Testosterone label lists its use as "replacement therapy in the male."
• Controlled substance: testosterone cypionate injection is a Schedule III controlled substance (CIII on its FDA label), so it requires a prescription.
• Injections specifically: the 2019 Global Consensus Position Statement on testosterone therapy for women, endorsed by groups including the International Menopause Society, The Endocrine Society and The North American Menopause Society, says "use of any testosterone preparation that results in supraphysiologic concentrations of testosterone, including pellets and injections, is not recommended." The VA summary agrees: "injections, pellets, and oral formulations of testosterone are not recommended due to the potential for supraphysiologic levels and risk of adverse effects."
• What testosterone is for: the Global Consensus says "the only evidence-based indication for testosterone for women is for HSDD," meaning postmenopausal women with hypoactive sexual desire disorder (low sexual desire that causes distress). The VA summary says other uses, such as for bone, mood or cognition, aren't recommended because of a lack of evidence. The option with the best support is a low, female-range dose of a transdermal product applied to the skin, used off-label with blood tests to monitor levels.

If you're interested in testosterone, see is there an FDA-approved testosterone for women?, testosterone therapy without injections, testosterone for menopause online and testosterone side effects in women.

HRT injections vs hormone pellets

Injections and pellets are both long-acting, and neither can be quickly reversed. The difference is approval: estradiol valerate and cypionate injections are FDA-approved for menopause hot flashes, while hormone pellets for women are typically compounded and not FDA-approved.

ACOG's 2023 Clinical Consensus says compounded bioidentical hormone therapy "should not be prescribed routinely when FDA-approved formulations exist." If you've been offered pellets, ask what FDA-approved routes were considered first. Our pellet safety guide explains how long pellets last and why removal isn't simple.

See are hormone pellets safe?, hormone pellets vs patch, hormone pellet therapy cost and compounded vs FDA-approved HRT.

Who might reasonably ask about estrogen injections?

No guideline we read names a group who should prefer injections. The reasons women raise them are practical: trouble with other routes, or a preference for a shot every few weeks over daily or weekly products. A clinician can tell you whether those reasons outweigh the tradeoffs for you.

Answer these honestly before your appointment. Each "yes" changes the conversation.

Reasons injections may be worth raising:

• Patches have caused rashes or won't stay on, and gels or sprays haven't worked or haven't been practical. See estradiol patch rash and estradiol patch won't stick.
• You want to avoid a daily pill, and transdermal routes aren't working for you.
• You struggle to remember daily or twice-weekly doses and would welcome a scheduled clinic visit.
• You've had trouble filling patches during a shortage. See estrogen patch shortage 2026.

Reasons to think twice:

• You want steady levels and the ability to stop or lower your dose quickly.
• You want the route with the most research behind it.
• You're uncomfortable with needles, or regular clinic visits would be hard to manage.
• You have a uterus and would rather keep your HRT simple. You'll still need a separate progestogen.
• Any contraindication on the label list above applies to you.

What do HRT injections cost, and does insurance cover them?

We didn't verify current prices for estradiol valerate or estradiol cypionate, so we don't quote any. Your total cost usually includes more than the vial, and coverage depends on your plan's formulary. Ask about each part before you start.

An unknown cost isn't zero, so a total missing any of these pieces is incomplete. For comparison shopping on other routes, see estradiol cost without insurance and does insurance cover HRT for menopause?.

How to get HRT injections for menopause

Start with a gynecologist, a menopause clinician or your primary care clinician who can give the shots or arrange them. Because MedlinePlus says these injections are usually given by a health professional, an in-person relationship usually matters more for this route than for patches, gels or pills.

Steps that help:

1. Write down your history. List the routes you've tried, what happened, your allergies (including sesame, castor oil or cottonseed), and any history of clots, stroke, heart disease, breast cancer or liver disease.
2. Ask whether injections fit your goals. Use the questions below.
3. Plan the progestogen if you have a uterus.
4. Agree on follow-up. Ask how your clinician will judge whether the dose is right, and when you'll review whether to continue, per the 3- to 6-month reviews the labels describe.

Online menopause services mostly prescribe products you use at home. In our medication map of online providers, checked July 2026, the only injections listed were testosterone injections, from one service with a broader longevity model, not estrogen injections. See which online HRT providers prescribe what and who can prescribe HRT for menopause.

Questions to ask your clinician about HRT injections

Bring these to your appointment, and talk with your clinician about how they apply to you:

1. Given my symptoms and history, why would an injection be better for me than a patch, gel, spray, ring or pill?
2. Which injection, estradiol valerate or estradiol cypionate, would you use, and why?
3. Who gives the shot, and how often will I need to come in?
4. What should I do if my symptoms return before my next shot?
5. If I have side effects, what happens, given that the dose can't be removed?
6. I have a uterus. Which progestogen will I take, and how?
7. Do any of my allergies matter for the oil or preservatives in the injection?
8. How will we decide whether my dose is right, and when will we review whether I still need it?
9. What will it cost me each month, including visits?
10. If I'm also interested in testosterone, what's the safest option for women, and why not injections?

Can online menopause care help if you're considering injections?

Online care can help you sort out which HRT route fits, and many women find a patch, gel, spray or pill that works without needing a shot. If you decide on injections, you'll most likely need an in-person clinic to give them. Here's how our five pillars apply:

• Clinical legitimacy: a licensed clinician should take a full history, including the routes you've tried, your allergies and your clot, heart and cancer history, before prescribing.
• Care quality: look for a service that explains route options and tradeoffs, not one that leads with a single product.
• Medication fit: the service should offer several FDA-approved routes, progestogen options if you have a uterus, and vaginal and nonhormonal options. Be cautious if a service leads with pellets or testosterone injections.
• Price transparency: you should know what visits, medication and refills cost before you start.
• Access: if you want estrogen injections, ask whether the service can work alongside a local clinic or whether in-person care should come first.

See is online HRT safe? and nonhormonal options if hormones aren't right for you.

If you're not sure whether a shot, a patch or something else fits your situation, start there.

Frequently asked questions

Are there HRT injections for menopause?

Yes. Estradiol valerate (Delestrogen and generics) and estradiol cypionate (Depo-Estradiol) are FDA-approved for moderate to severe hot flashes of menopause. They're usually given by a health professional every 3 to 4 weeks. They're used less often than pills, patches, gels and sprays.

Are estrogen shots better than patches?

Not for most women, based on the sources we read. Patches are designed for steady daily delivery and can be removed, and transdermal estrogen hasn't been linked with clot risk in observational studies. Injections give a peak and a decline between shots and can't be taken back. They may be worth discussing if other routes haven't worked.

How long does an estrogen injection last?

The FDA labels say a single injection "is absorbed over several weeks," and MedlinePlus says the shots are usually given every 3 to 4 weeks. Levels peak within a few days and then fall.

How fast do estrogen injections work for hot flashes?

MedlinePlus says symptoms "should improve within 1 to 5 days" after the injection. Tell your clinician if they don't.

Do I need progesterone with estrogen injections?

If you have a uterus, yes. Both estrogen injection labels say a progestin should be started with estrogen to lower the risk of endometrial cancer. Women without a uterus don't need one.

Can I give myself estrogen injections at home?

MedlinePlus says these shots are usually given by a health professional. Whether home injection is an option is a decision for your clinician, who would need to teach you how to do it safely.

Are testosterone injections safe for women in menopause?

They aren't recommended. No testosterone product is FDA-approved for women in the US, and the 2019 Global Consensus says preparations that push levels above the female range, including injections, aren't recommended. Low-dose transdermal testosterone, used off-label for low sexual desire, has the best evidence.

Are hormone injections the same as hormone pellets?

No. Estradiol injections are FDA-approved, are given into a muscle and last weeks. Pellets are placed under the skin, are usually compounded and not FDA-approved, and last months. Neither can be quickly reversed.

Can Find My HRT Path tell me if injections are right for me?

No. Find My HRT Path asks about your symptoms, what you've tried, your age, your state and your health history to suggest a care option. It doesn't choose a route or make a prescription decision. A clinician who knows your history does that.

The bottom line

HRT injections for menopause are real and FDA-approved: estradiol valerate and estradiol cypionate shots can treat moderate to severe hot flashes. But they're a niche route. They're usually given in a clinic every 3 to 4 weeks, levels rise and fall between shots, a dose can't be taken back, and the major guidelines list pills, patches, gels, sprays and rings rather than injections. If you have a uterus, you'll still need a progestogen. Testosterone injections are a separate issue: no US product is approved for women, and experts advise against injections. If patches, gels and pills haven't worked for you, an estrogen injection is a fair question to bring to a gynecologist or menopause clinician.

If you're still sorting out which route and which kind of care fits, Find My HRT Path can point you to a starting option and flag when in-person care should come first.

Related reading

• Types of HRT
• Oral vs transdermal estrogen
• Estradiol patch vs pill
• Hormone pellets vs patch
• Testosterone therapy without injections
• Do you need progesterone if you have a uterus?
• Who should not take HRT
• Compounded vs FDA-approved HRT

Sources

All sources were read on November 2, 2026.

1. Delestrogen (estradiol valerate injection, USP) prescribing information, Par Health USA, label dated May 20, 2026. DailyMed, US National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e8f94df9-0692-4462-a7f0-fe019a0a3f07
2. Depo-Estradiol (estradiol cypionate injection, USP) prescribing information, Pharmacia & Upjohn, label dated February 29, 2024. DailyMed, US National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9a4229fd-fecd-4ac1-9c4f-6d442533457f
3. Estradiol valerate injection (generic) prescribing information, Hikma Pharmaceuticals. DailyMed, US National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=66f40ab0-4432-4e85-b709-a0bc076868c6
4. Depo-Testosterone (testosterone cypionate injection, USP, CIII) prescribing information, Pharmacia & Upjohn, label dated August 20, 2026. DailyMed, US National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cfbb53d4-b868-4a28-8436-f9112eb01c39
5. MedlinePlus. Estrogen injection. US National Library of Medicine (AHFS Patient Medication Information; page last reviewed September 1, 2010). https://medlineplus.gov/druginfo/meds/a606004.html
6. The 2022 hormone therapy position statement of The North American Menopause Society (The Menopause Society). Menopause, 2022;29(7):767–794. https://menopause.org/wp-content/uploads/professional/nams-2022-hormone-therapy-position-statement.pdf
7. American College of Obstetricians and Gynecologists. Hormone therapy for menopause (FAQ517). Last updated October 2021, last reviewed February 2024. https://www.acog.org/womens-health/faqs/hormone-therapy-for-menopause
8. American College of Obstetricians and Gynecologists. Compounded bioidentical menopausal hormone therapy. Clinical Consensus Number 6, November 2023, reaffirmed 2026 (abstract). https://www.acog.org/clinical/clinical-guidance/clinical-consensus/articles/2023/11/compounded-bioidentical-menopausal-hormone-therapy
9. Davis SR, Baber R, Panay N, et al. Global Consensus Position Statement on the use of testosterone therapy for women. Journal of Clinical Endocrinology & Metabolism, 2019;104(10):4660–4666. https://pmc.ncbi.nlm.nih.gov/articles/PMC6821450/
10. VA Pharmacy Benefits Management Services and National Formulary Committee. Transdermal testosterone (off-label) for hypoactive sexual desire disorder in postmenopausal females: summary guidance. March 2025. https://www.va.gov/formularyadvisor/DOC_PDF/CRE_Testosterone_HSDD_Clinical_Summary_Mar_2025.pdf
11. Oriowo MA, Landgren BM, Stenström B, Diczfalusy E. A comparison of the pharmacokinetic properties of three estradiol esters. Contraception, 1980;21(4):415–424. https://pubmed.ncbi.nlm.nih.gov/7389356/
12. Femring (estradiol acetate vaginal ring) prescribing information, Millicent US, label dated December 19, 2025. DailyMed, US National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7aaa97f9-a9d1-c815-e053-2991aa0afb9e
13. US Food and Drug Administration. FDA approves labeling changes to menopausal hormone therapy products. Press announcement, February 12, 2026. https://www.fda.gov/news-events/press-announcements/fda-approves-labeling-changes-menopausal-hormone-therapy-products

This page is for education only and is not medical advice. It doesn't replace an examination, diagnosis or treatment plan from a clinician who knows your health history. Don't start, stop or change any hormone treatment without talking with your clinician. If you have chest pain, sudden shortness of breath, sudden severe headache, vision or speech changes, or a painful swollen leg, call 911.