Activella Reviews: What Women Report, What the Label Shows and Real-World Tips

By The HRT Index Editorial Team · Editorial research — not medically reviewed · Last verified October 2026

Activella reviews are mixed. On October 31, 2026, Drugs.com showed 5.9 out of 10 from 25 reviews, while 47 of 77 WebMD reviews describing the Activella-type pill gave 4 or 5 stars. Women praise fast hot flash relief and better sleep. Common complaints are early bleeding, breast tenderness, weight gain, hair shedding and mood changes.

The HRT Index is the independent decision resource for online menopause and HRT care — comparing telehealth providers on clinical legitimacy, care quality, medication fit, price transparency, and access, with every claim verified and dated, so women can choose the path that fits their situation before their first consult.

What we actually verified · Last verified October 2026

• What we read: all 25 Activella reviews on Drugs.com, one by one; the 3 Mimvey reviews on Drugs.com; all 393 reviews on WebMD's shared estradiol/norethindrone review page, which pools Activella and its generics with the CombiPatch skin patch, read one by one to find every review that describes taking the pill (we found 77); the current Activella prescribing information and patient information on DailyMed, including its clinical trial, side effect and bleeding data; The Menopause Society's 2022 hormone therapy position statement; MedlinePlus patient information on estrogen and progestin hormone therapy; the FDA's November 2025 request to change menopause hormone therapy labels, its February 2026 approval announcement and its list of updated labels; and the FDA's generic drug facts page. Every source is listed at the bottom with the date we read it.
• What we did not do: we did not take Activella ourselves, contact reviewers, examine anyone or speak with a clinician for this page. We didn't write or edit any review, and we don't publish star ratings of our own. This is editorial research, not medical review, and not advice for your situation.
• Commercial interest: The HRT Index may earn a commission from some providers featured through The HRT Index's Find My HRT Path tool. No drug maker or provider paid for this page or reviewed it, and we don't earn anything from Activella sales. See our affiliate disclosure.
• Verification Standard: we judge online menopause care on five pillars, in this order: clinical legitimacy, care quality, medication fit, price transparency and access. Our methodology explains how.

Jump to: Scorecard · What it is · What reviews say · Does it work? · Bleeding and spotting · Side effects · Weight, hair and mood · Brand vs generic · Boxed warning and FDA changes · Who shouldn't take it · Cost and coverage · Activella vs other options · Who tends to do well · Questions to ask · Online care · FAQ · Sources

Activella reviews at a glance: the scorecard

Here's the short version, built from the review data we read on October 31, 2026 and from the FDA label. We don't give Activella a score of our own. Reviews are personal, unverified reports, so we treat them as a guide to what to ask about, not proof of what will happen to you.

What Activella is, in plain terms

Activella is a daily tablet that contains two hormones: estradiol, the main estrogen your ovaries make before menopause, and norethindrone acetate, a progestin. It's a "continuous combined" product, which means you take the same estrogen-plus-progestin tablet every day with no break. The brand was approved in 1998. The current label on DailyMed is from Amneal, and the Activella trademark belongs to Novo Nordisk Health Care AG. Several reviewers, apparently outside the US, call it Activelle.

According to the FDA label, Activella is approved for women who have a uterus, for:

• Moderate to severe hot flashes and night sweats (the label calls them vasomotor symptoms) due to menopause
• Moderate to severe vaginal dryness and related symptoms due to menopause, with the 1 mg/0.5 mg strength only. The label says that when you're treating only vaginal symptoms, topical vaginal products should be considered first.
• Preventing osteoporosis after menopause, for women at significant risk. The label says non-estrogen medicines should be considered first when bone protection is the only goal.

A few facts from the label shape almost every review:

• It's for women who still have a uterus. The progestin is there to protect the lining of the uterus from estrogen. The patient information says plainly: "Do not use ACTIVELLA if you have had your uterus (womb) removed (hysterectomy)." If you've had a hysterectomy, estrogen alone is usually the option to discuss. See HRT after hysterectomy.
• There are two strengths. Activella 1 mg/0.5 mg has 1 mg of estradiol and 0.5 mg of norethindrone acetate. Activella 0.5 mg/0.1 mg is the lower dose that reviewers often call "Activella LD" or "lowest dose."
• You take one tablet a day. The patient information says to take 1 tablet at the same time each day, and to talk with your clinician every 3 to 6 months about your dose and whether you still need it.
• It's a pill, so it goes through the liver first. That matters when you compare it with patches, gels and rings. Our guide to oral vs transdermal estrogen explains why.

The other names you'll see

On October 31, 2026, Drugs.com listed several other brand names for the same combination, including Mimvey, Mimvey Lo, Lopreeza, Amabelz, Abigale, Abigale Lo, Etyqa and Ena. On WebMD, 10 of the pill reviews name Mimvey and 2 name Lopreeza. Drugs.com had only 3 Mimvey reviews, averaging 5.3 out of 10, too few to say much. Our Activella cost guide and Mimvey cost guide cover these versions.

One important trap: Drugs.com's main estradiol/norethindrone page showed 6.5 out of 10 from 105 reviews on October 31, 2026, but that figure pools Activella with CombiPatch, a skin patch with the same two hormones. It isn't an Activella rating. The same goes for WebMD's 3.8 out of 5 from 393 reviews, which includes many CombiPatch reviews. If you're looking at the patch, see our CombiPatch reviews.

What Activella reviews say: patterns from about 100 real reviews

We read 25 Activella reviews on Drugs.com and the 77 WebMD reviews that describe taking the estradiol/norethindrone pill, whether they called it Activella, Activelle, Mimvey, Lopreeza or simply a generic. That's 102 posts. At least 2 people appear to have posted on both sites, one WebMD reviewer posted twice, and one Drugs.com review describes the writer's mother rather than her own use, so the real number of women is about 100.

Most of these reviews are old. On WebMD, 60 of the 77 were posted between 2007 and 2014, and only 7 since 2020. On Drugs.com, reviews run from 2010 to 2025. Brands, generics and labels have changed since then, so treat older reviews as background.

The right online menopause care isn't the same for every woman — it depends on your symptoms, what you've already tried, your age, your state and your health history. Some situations belong with an in-person clinician first. Use The HRT Index's Find My HRT Path tool to explore a featured care option for your situation — and to flag when online care isn't the right starting point — before your first consult.

Find My HRT Path is free, takes about 60 seconds and doesn't ask for your email. It asks about your symptoms, what you've already tried, your age, your state and your health history. It isn't an eligibility test or a diagnosis, and it can't tell you whether Activella is right for you.

What reviewers liked

• Hot flash and night sweat relief. This is the most common praise on both sites. A Drugs.com reviewer who'd used it for 8 years wrote that it "was the only HRT that makes me feel like my old self." Another, on the low dose, wrote: "It took about 3 weeks to work, but it works."
• Sleep. Several women said they slept through the night again, some within the first week.
• Mood and anxiety. On Drugs.com, 4 reviewers said they felt calmer, less anxious or irritable, or less depressed. On WebMD, about 9 said the same. One wrote that after 3 days she "didn't have any anxiety."
• Fewer migraines for some. One Drugs.com reviewer and 3 on WebMD said hormonal headaches or migraines eased. (Others had the opposite experience, below.)
• Long-term satisfaction. 6 Drugs.com reviewers and 15 WebMD reviewers had taken it for 5 years or more, and most of them were happy with it. One WebMD reviewer in her 60s had used it for about 9 years and wrote that she "Would never want to go back to having those hot flashes again!"
• No bleeding for some. One WebMD reviewer switched to the pill from a combination patch because of constant spotting and said the bleeding stopped after the second pill.

What reviewers didn't like

• Bleeding or spotting, sometimes heavy, sometimes after months without a period.
• Breast tenderness or pain.
• Weight gain and bloating.
• Hair shedding or thinning.
• Mood changes, including irritability, tearfulness, anxiety and low mood.
• Headaches or migraines.
• Feeling worse at first. Some stopped within days or weeks.
• Generic switches. Some felt their symptoms came back after a pharmacy or insurance switch.
• The blister pack. One reviewer said getting the pills out of the package was "almost impossible."

Here's how often each theme came up. We counted each reviewer once per theme.

Who wrote these reviews

On WebMD, 45 of the 77 pill reviewers said they were 45 to 54, and 25 were 55 to 64. Only 3 were 35 to 44, and 2 were 65 to 74. That's the age group the label and The Menopause Society have most in mind when they talk about starting hormone therapy. A few reviewers were in their late 60s and had taken it for more than a decade.

Several reviewers had tried other hormone therapy first, such as Prempro, a combination patch or separate estrogen and progesterone, before landing on Activella. Some did better on Activella and some did better on what they'd used before. That's a reminder that the best option varies from woman to woman.

Things in the reviews to be careful with

Reviews are honest experiences, but some contain things you shouldn't copy:

• Changing the dose on your own. At least 4 reviewers described cutting tablets in half, taking them every other day or every few days, or weaning themselves. The label says to take 1 tablet a day as prescribed. Changing that can affect how well the progestin protects your uterus and can cause bleeding. Talk with your clinician first. Our guide to HRT dose adjustment explains how it's usually done.
• "It's just side effects." A few reviewers kept going through symptoms the label says need prompt attention, such as calf pain or new bleeding. See when to get help.
• Smoking. Two reviewers who reported heart or leg problems also said they smoked. The patient information says using tobacco may raise your risk of heart disease, and MedlinePlus says smoking increases the risk of serious side effects such as blood clots and stroke. See best HRT for smokers.
• Taking it after a hysterectomy. The patient information says not to use Activella if you've had your uterus removed.

Does Activella work? What the trials found

Hot flashes

The label describes two trials:

The label shows these results as graphs rather than exact percentages, so we can't give you a percentage drop.

Protecting the uterus

This is why the progestin is there. In a 1-year trial of 1,176 women described on the label, 36 of 247 women (14.6%) taking 1 mg of estradiol alone developed endometrial hyperplasia, an overgrowth of the uterine lining that can lead to cancer. On Activella 1 mg/0.5 mg, 1 of 241 women (0.4%) did.

Bones

In two 2-year trials on the label, bone density at the lower spine rose on Activella and fell on placebo. In the US trial, it rose 3.8% on Activella and fell 2.1% on placebo. In the European trial, it rose 5.4% and fell 0.9%.

How fast does it work?

The label shows a significant difference from placebo by week 4. Reviewers' timelines varied. Some felt better within 3 days, several in 1 to 2 weeks, and two Drugs.com reviewers said about 3 weeks. A few said it took about 2 months. Our guide to how long until HRT starts working goes further.

What The Menopause Society says

The Menopause Society's 2022 position statement says hormone therapy "remains the most effective treatment" for hot flashes and the genitourinary syndrome of menopause. It says women with a uterus who use systemic estrogen "should receive adequate progestogen" to protect the uterine lining. When it discusses blood clots and stroke, it notes that limited observational data and a systematic review suggest less risk with transdermal hormone therapy than oral, but that comparative randomized trial data are lacking. Our norethindrone vs micronized progesterone guide compares the progestin in Activella with the progesterone some women take instead.

Bleeding and spotting on Activella

Bleeding is one of the biggest reasons women give for loving or leaving Activella.

What the label says: during the first months, irregular bleeding or spotting happened on Activella 1 mg/0.5 mg, but "bleeding tended to decrease over time." After 12 months, about 86% of women on that dose had no bleeding. On the 0.5 mg/0.1 mg dose, 88% had no bleeding after 6 months. In the low-dose trial's side effect table, vaginal bleeding was reported by 26% of women on Activella vs 12% on placebo.

What reviewers say: 11 reviewers described bleeding or spotting. Some said it was light and short. One WebMD reviewer on the lowest dose said she got a period within a week that hadn't stopped 3 weeks later. A Drugs.com reviewer on a generic lowest dose described heavy bleeding along with urethral and vaginal irritation. Another said things were great for 3 weeks before period-like pain and spotting started. One WebMD reviewer had bleeding for the first time in 4 years and was booking a doctor's appointment, which is the right move.

What to do: the label tells women to report any vaginal bleeding after menopause to their healthcare provider as soon as possible. Don't assume it's "just the pill," and don't cut your dose to stop it. For more, see bleeding after starting HRT, spotting on HRT and continuous vs cyclic HRT.

Activella side effects: what the trials and reviewers report

The most common side effects on the label

The patient information lists these common side effects: irregular vaginal bleeding or spotting, nausea, stomach or abdominal cramps, bloating, headache, vomiting, back pain, breast pain, diarrhea, fluid retention and vaginal yeast infection.

Here's what the label's trials found for side effects reviewers often mention:

The bone and hot flash trials were small, so these percentages are rough. Our HRT side effects guide covers side effects across hormone therapy.

What reviewers add

Reviewers described the same things plus a few others. On Drugs.com, one reviewer had daily morning diarrhea that seemed to be easing at 5 weeks. On WebMD, several mentioned nighttime nausea, bloating or vaginal discharge. Reviewers also described rare but serious problems: one woman was diagnosed with a blood clot in her leg after 7 months and stopped (she appears to have posted on both sites), and individual reviewers reported breast cancer, hives or facial swelling, blurred vision, and a meningioma, a usually noncancerous brain tumor. A review can't tell you whether the pill caused any of these. But they line up with the warning signs the label tells you to act on. If you've had a meningioma, see HRT with a meningioma.

When to get help

The patient information says to call your healthcare provider right away if you have:

• New breast lumps
• Unusual vaginal bleeding
• Changes in vision or speech
• Sudden new severe headaches
• Severe pains in your chest or legs, with or without shortness of breath, weakness and fatigue

Call 911 for chest pain, sudden shortness of breath, sudden weakness on one side, trouble speaking or seeing, or swelling of your face, lips or tongue. If you get a migraine with aura, see HRT and migraine with aura and raise it with your clinician. The label also says that, if feasible, estrogen should be stopped at least 4 to 6 weeks before surgery linked to a higher clot risk, or during long periods of immobility. Tell anyone planning surgery that you take it.

Interactions

The label says CYP3A4 inhibitors such as some antibiotics and antifungals, and grapefruit juice, may raise estrogen levels, while inducers such as St. John's wort may lower them and change your bleeding pattern. Tell your clinician and pharmacist about everything you take. The tablets contain lactose monohydrate, which matters if your clinician has told you to avoid lactose.

Weight, hair and mood: the complaints that come up most

Weight

Weight gain is the most common complaint on WebMD's pill reviews, with 14 mentions there and 1 on Drugs.com. Reviewers gave figures from about 5 pounds to close to 30 pounds. One said she couldn't say the gain was directly related to the pill. Another said her doctor told her the weight gain was normal at 50. On the other side, one reviewer who'd taken Activella for 5 years lost and kept off 50 pounds and wrote that "weight gain is not inevitable on this drug."

The label's 2-year bone trial found weight increase in 9% of women on Activella vs 6% on placebo, a small study. "Increase or decrease in weight" and edema also appear in the post-approval list, which the label says can't be used to estimate frequency or prove cause. Our guide to whether HRT causes weight gain covers the wider evidence.

Hair

10 WebMD reviewers described hair shedding or thinning, and at least 3 stopped or planned to switch because of it. One said it started about 2 months in and she lost a large share of her hair in under a year. Another said it eased after a couple of months, and one long-term user noticed it after her dose was lowered. "Loss of scalp hair" is on the label's post-approval list, without a frequency. Hair loss at midlife has many causes, so it's worth getting checked rather than assuming. See what HRT helps with hair.

Mood

Mood cuts both ways. On WebMD, 13 pill reviewers said they felt more irritable, tearful, anxious or low, and on Drugs.com 4 did. But many others said their anxiety and irritability lifted. Emotional lability was 6% on Activella vs 0% on placebo in the small bone trial, and depression and mood disturbances appear in the post-approval list. If your mood drops on any hormone therapy, tell your clinician. If you ever have thoughts of harming yourself, call or text 988.

Activella brand vs generic: what reviewers say

This is one of the most emotional topics in the reviews. On Drugs.com, one long-term user wrote: "Generics do NOT work for me." Another said scalp acne started on a generic and seemed to clear on the brand. On WebMD, 5 reviewers said their hot flashes or mood got worse after a pharmacy or insurance switch, and one said her doctor had told her there were too many problems with the generic.

Others had the opposite experience. One WebMD reviewer wrote: "This generic of Activella has totally changed my life around." Another said she could feel the difference immediately on the generic. A reviewer who did badly on one generic said a different maker's generic had worked fine.

The FDA says approved generic medicines "work in the same way and provide the same clinical benefit and risks as their brand-name counterparts." Individual experiences vary, and a review can't separate a switch from other changes happening at the same time. If you feel different after a switch, note when it started, check the maker on your label, and tell your clinician and pharmacist. You can also report it to the FDA's MedWatch program.

The boxed warning, and what the FDA's 2025–2026 changes mean for Activella

The current label still has the full boxed warning

The Activella label on DailyMed (published June 2024) carries a boxed warning for cardiovascular disorders, probable dementia, breast cancer and endometrial cancer. It's based mainly on the Women's Health Initiative (WHI), a large trial that used oral conjugated estrogens plus medroxyprogesterone acetate, not Activella. The label says that, without comparable data, the risks should be assumed to be similar for other estrogen and progestin products.

In the WHI estrogen-plus-progestin study (average age 63), the label reports these extra events per 10,000 women each year compared with placebo: 7 more heart disease events, 8 more strokes, 10 more blood clots in the lungs and 8 more invasive breast cancers. It also reports 6 fewer colorectal cancers and 5 fewer hip fractures. See HRT and blood clots and HRT and breast cancer risk.

What the FDA changed

On November 10, 2025, the FDA asked makers of menopause hormone therapy to change their labels. For all products, it asked them to take language about cardiovascular disease, breast cancer and probable dementia out of the boxed warning, and to remove the advice to use the lowest dose for the shortest time. Cardiovascular and breast cancer warnings stay in the body of the label.

On February 12, 2026, the FDA announced it had approved the first updated labels. When we checked the FDA's list of products with updated prescribing information on October 31, 2026, Activella was not on it, and neither were Mimvey, Amabelz, Lopreeza or Prempro. Bijuva, an estradiol and progesterone capsule, was.

What that means for you

Until Activella's label is updated, it still shows the older boxed warning. The Menopause Society's 2022 statement says that for women under 60 or within 10 years of menopause onset who have no contraindications, the benefit-risk ratio is favorable for treating bothersome hot flashes and preventing bone loss, and that the balance appears less favorable for women who start more than 10 years after menopause or after age 60. How that applies to you is a conversation for your clinician. Our menopause hormone therapy safety update explains the changes in more detail.

The patient information also says to have a breast exam and pelvic exam each year, a mammogram every year unless your clinician tells you otherwise, and to talk with your clinician every 3 to 6 months about whether you still need treatment.

Who shouldn't take Activella

According to the label, you shouldn't take Activella if you have or have had:

• Unusual vaginal bleeding that hasn't been diagnosed
• Breast cancer, or a history of it
• A known or suspected cancer that's sensitive to estrogen
• A blood clot in your legs or lungs, now or in the past
• A stroke or heart attack, now or in the past
• Liver problems or liver disease
• A known blood clotting disorder, such as protein C, protein S or antithrombin deficiency
• A serious allergic reaction to Activella or any of its ingredients

The patient information also says not to use it if you've had a hysterectomy. Our who should not take HRT guide explains these in plain language. If any apply to you, talk with a clinician about nonhormonal options.

Activella cost, coverage and availability

Cost and coverage come up often in the reviews, usually as a reason someone was switched to a generic or to a different product. Prices change and vary by pharmacy, plan and dose, so we don't quote them here. Our Activella cost without insurance and Mimvey cost without insurance guides compare what to expect and the versions available.

One Drugs.com reviewer in January 2022 said her pharmacy had been waiting weeks for a shipment of the brand. On October 31, 2026, the brand still had a current label on DailyMed.

Activella vs other options: how reviews and labels compare

Two WebMD reviewers said Activella didn't fix vaginal dryness, and both added a vaginal estrogen tablet. Others said dryness improved. If vaginal symptoms are your main issue, ask about local vaginal treatment.

Who tends to do well on Activella, and who struggles

Based on the patterns in the reviews and what the label says, women who seemed to do well often:

• Had a uterus and wanted one pill instead of two prescriptions
• Mainly had hot flashes, night sweats and poor sleep
• Got through the first few weeks of spotting or adjustment
• Had a clinician who checked in and adjusted the plan

Women who struggled often:

• Had ongoing bleeding or breast tenderness that didn't settle
• Noticed weight gain, hair thinning or mood changes
• Had migraines get worse
• Felt worse after a switch between brands or generics
• Needed more flexibility than a fixed-dose combination allows

None of this predicts your experience. It just shows what to watch for and what to ask.

Questions to ask your clinician about Activella

• Is a combined pill right for me, or would separate estrogen and progesterone, or a patch or gel, fit better?
• Which strength should I start on, and when will we review it?
• How much bleeding is expected in the first months, and when should I call?
• What should I do if my symptoms get worse in the first weeks?
• Does my migraine, clot, stroke, liver or breast history change the choice?
• If my pharmacy switches the maker, what should I watch for?
• How long should I plan to take it, and how would we stop it if I want to?

Stopping can bring hot flashes back, as 10 reviewers described. See what happens when you stop HRT.

Can you get Activella through online menopause care?

Some online menopause services prescribe combined estrogen and progestin pills, though which products they offer varies. Our Activella online prescription guide and Mimvey online prescription guide cover what to expect. Here's how our five pillars apply:

• Clinical legitimacy: a licensed clinician should take a full history before prescribing, including any abnormal bleeding, hysterectomy and any history of breast cancer, clots, stroke, heart disease, migraine or liver disease.
• Care quality: look for clear follow-up, a plan for side effects and unexpected bleeding, and a route to in-person care when you need an exam.
• Medication fit: a good service can discuss more than one option, such as a combined pill, separate estrogen and progesterone, a patch or gel, and nonhormonal choices if hormones aren't right for you.
• Price transparency: you should know what visits, refills and the medicine itself are likely to cost before you start.
• Access: you'll still need regular breast and pelvic exams and mammograms, and new or unusual bleeding needs an in-person evaluation.

See is online HRT safe? for how to judge a service.

Frequently asked questions

Are Activella reviews mostly good or bad?

Mixed. On October 31, 2026, Drugs.com showed 5.9 out of 10 from 25 reviews, with 48% positive and 40% negative. On WebMD, 47 of 77 pill reviews gave 4 or 5 stars. Women often praise hot flash relief, and the main complaints are bleeding, breast tenderness, weight, hair and mood.

How long does Activella take to work?

The label's trials showed a significant drop in hot flashes compared with placebo by week 4. Reviewers described anything from a few days to about 3 weeks, and a few said about 2 months.

Does Activella cause weight gain?

Some women report it. Weight gain came up in 15 of the reviews we read. In a 2-year label study, weight increase was 9% on Activella vs 6% on placebo. One long-term user lost 50 pounds while taking it.

Is bleeding normal on Activella?

Irregular bleeding or spotting is common in the first months and tends to fade. The label says about 86% of women on the 1 mg/0.5 mg dose had no bleeding after 12 months. Report any vaginal bleeding to your clinician as soon as possible.

Does Activella cause hair loss?

Ten WebMD reviewers reported hair thinning. "Loss of scalp hair" is on the label's post-approval list without a frequency, and the label says those reports can't prove cause. If you notice shedding, talk with your clinician.

Is generic Activella the same as the brand?

The FDA says approved generics work the same way, with the same benefits and risks. Some reviewers still felt different after a switch, while others did well on generics. Tell your clinician and pharmacist if you notice a change.

Can you take Activella after a hysterectomy?

The patient information says not to use Activella if you've had your uterus removed. Women without a uterus usually don't need a progestin.

Does Activella still have a black box warning?

Yes. When we checked on October 31, 2026, Activella wasn't on the FDA's list of products with updated labels, and its DailyMed label still showed the boxed warning for cardiovascular disorders, probable dementia, breast cancer and endometrial cancer.

Can Find My HRT Path tell me if Activella is right for me?

No. Find My HRT Path asks about your symptoms, what you've tried, your age, your state and your health history, and points you to a featured care option or flags when online care isn't the right start. Only a clinician who knows your history can decide on a prescription.

The bottom line

Activella reviews are split. Many women say it ended their hot flashes and night sweats and gave them their sleep back, some for 10 years or more, and the label's trials back up the hot flash and bone benefits. But bleeding, breast tenderness, weight gain, hair thinning and mood changes come up again and again, and several women felt worse after generic switches. It's for women who still have a uterus, it carries the full boxed warning on its current label, and any bleeding or warning sign needs a call to your clinician.

If you're weighing Activella against other ways to treat menopause symptoms, Find My HRT Path can help you see what fits and flag when in-person care should come first.

Related reading

• Activella cost without insurance
• Activella online prescription
• Activella vs Bijuva
• Angeliq vs Activella
• Mimvey online prescription
• Continuous vs cyclic HRT
• CombiPatch reviews
• Estradiol pill reviews

Sources

All sources were read on October 31, 2026.

1. Activella (estradiol/norethindrone acetate tablets) prescribing information and patient information, Amneal Pharmaceuticals. DailyMed, US National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d4b0c1dd-aae9-4ca2-958c-71dbe5d0fab0
2. Activella user reviews and ratings. Drugs.com. https://www.drugs.com/comments/estradiol-norethindrone/activella.html
3. Mimvey user reviews and ratings. Drugs.com. https://www.drugs.com/comments/estradiol-norethindrone/mimvey.html
4. Estradiol/norethindrone user reviews and ratings. Drugs.com. https://www.drugs.com/comments/estradiol-norethindrone/
5. Estradiol/norethindrone (CombiPatch, Activella and others) user reviews. WebMD. https://reviews.webmd.com/drugs/drugreview-estradiol-norethindrone-combipatch-activella-and-others
6. The 2022 hormone therapy position statement of The North American Menopause Society. Menopause, 2022;29(7):767–794. https://pubmed.ncbi.nlm.nih.gov/35797481/
7. Estrogen and Progestin (Hormone Replacement Therapy). MedlinePlus Drug Information, US National Library of Medicine. https://medlineplus.gov/druginfo/meds/a601041.html
8. US Food and Drug Administration. FDA requests labeling changes related to safety information to clarify benefit/risk considerations of menopausal hormone therapy (November 10, 2025). https://www.fda.gov/drugs/drug-alerts-and-statements/fda-requests-labeling-changes-related-safety-information-clarify-benefitrisk-considerations
9. US Food and Drug Administration. FDA approves labeling changes for menopausal hormone therapy products (February 12, 2026). https://www.fda.gov/news-events/press-announcements/fda-approves-labeling-changes-menopausal-hormone-therapy-products
10. US Food and Drug Administration. Menopausal hormone therapies with updated prescribing information. https://www.fda.gov/drugs/drug-safety-and-availability/menopausal-hormone-therapies-updated-prescribing-information
11. US Food and Drug Administration. Generic drug facts. https://www.fda.gov/drugs/generic-drugs/generic-drug-facts
12. US Food and Drug Administration. MedWatch: the FDA safety information and adverse event reporting program. https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program

This page is for education only and is not medical advice. It doesn't replace an examination, diagnosis or treatment plan from a clinician who knows your health history. If you have unusual vaginal bleeding, a new breast lump, changes in vision or speech, a sudden severe headache, severe pain in your chest or legs, or swelling of your face, lips or tongue while taking Activella, contact a clinician promptly or call 911 in an emergency. You can report side effects to the FDA through MedWatch at 1-800-FDA-1088.